KORELASI ANTARA KADAR INTERFERON-γ PLASMA DENGAN JUMLAH VIRAL LOAD DI PENDERITA HIV

Abstract

The incidence of HIV is increasing in Indonesia and Asia as well, Indonesia is considered as the most rapid. One of the diagnostic tools
for diagnosing HIV is by viral load. Lymphocyte T-CD8+ secreted IFN-γ will inhibit replication of HIV virus through the induction of antiviral
protein and the host immune response, which kills infected cells. An examination of plasma IFN-γ and viral load will be more convincing
for the treatment and/or to know the progressiveness of HIV & AIDS. The aim of this study is to know the correlation between plasma IFN-γ
and viral load in HIV patients. Forty two samples from HIV patients were collected at the Intermediate Care and Infectious Disease Unit of
Dr. Soetomo Hospital, Surabaya from April to June 2011. The concentration of plasma IFN-γ was measured by ELISA (eBioscience) method
and the amount of viral load was measured using PCR Cobas Amplicor (Roche Diagnostics). The level of plasma IFN-γ in this study was
found 11.4 pg/mL up to 576 pg/mL and the level of viral load was 589 copies/mL up to 510.000 copies/mL. The statistical analysis showed
no significant correlation (p>0.05) between plasma IFN-γ level and viral load in HIV patients, and no correlation was found between IFN-γ
plasma and viral load in HIV patients.