SINDROM HORMON ANTIDIURETIK BERLEBIH

Arleen N. Suryatenggara, Dalima A. W. Astrawinata

Abstract


Syndrome of Inappropiate Antidiuretic Hormone (SIADH) is a condition caused by excessive antidiuretic hormone (ADH) secretion.
High level of ADH increse water reabsorption in the kidney. This syndrome is characterized by hyponatremia, plasma hypo-osmolality,
urine osmolality less than 100 mOsm/kg, elevated urine sodium, euvolemia, with normal renal, adrenal, and thyroid function. SIADH
could be the result of ectopic ADH caused by malignant cells, drug-induced, baroreceptor lesion, and other problems. Main treatment
for SIADH is intended to overcome the underlying diseases. Other approaches are by fluid restriction, salt supplementation, and the use
of drugs inducing diabetes insipidus or V2 receptor antagonist.


Keywords


Syndrome of inappropriate antidiuretic hormone, hyponatremia, paraneoplastic syndrome

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DOI: http://dx.doi.org/10.24293/ijcpml.v18i2.1013

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