DIAGNOSIS JANGKITAN (INFEKSI) VIRUS DENGUE DENGAN UJI CEPAT (RAPID TEST) IgA ANTI-DENGUE

Authors

  • Sri Kartika Sari
  • Aryati Aryati

DOI:

https://doi.org/10.24293/ijcpml.v17i2.1020

Keywords:

IgA anti-dengue rapid test, dengue virus infection

Abstract

Dengue IgM, IgG Capture ELISAs and NS1 Ag ELISA become the most widely used serological methods for dengue diagnosis until
now. Previous studies reported a possible use of IgA antibodies for dengue virus as a new serologic marker to make dengue infection
active. In the present study, the performance of IgA anti-dengue rapid test as a new marker of dengue infection was assessed. In this
study, the sera were obtained from 30 dengue virus infection patients and 30 non dengue virus infection patients. Thirty dengue paired
sera were collected twice, at the time of hospital admission (acute) and at discharge (convalescent). All sera samples were characterized
using dengue reference ELISAs (NS1 Ag, Dengue IgM and IgG capture ELISAs). The results of IgA anti-dengue rapid test were compared
with the corresponding dengue reference tests. The sensitivity and specificity of IgA anti-dengue rapid test respectively were 78.3% (95%
CI: 65.5–87.5%), and 73.3% (95% CI: 55,6–85,8%). Meanwhile, from acute sera, sensitivity of IgA anti-dengue rapid test was 83.3%
(95% CI: 64.5–93.7), higher than IgM (73.3%, 95% CI: 53.8–87.0), IgG (66.7%, 95% CI: 47.1–82.1) and NS1 Ag ELISAs (60%,
95% CI: 40.7–76.8). Positive IgA anti-dengue rapid test results in acute sera was higher in the secondary (91%) than primary infection
(57%). IgA anti-dengue rapid test can be considered as a new marker for dengue infection, because it gives a high sensitivity, especially
in the acute phase and in the secondary infections as well.

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Submitted

2018-03-17

Accepted

2018-03-17

Published

2018-03-17

How to Cite

[1]
Kartika Sari, S. and Aryati, A. 2018. DIAGNOSIS JANGKITAN (INFEKSI) VIRUS DENGUE DENGAN UJI CEPAT (RAPID TEST) IgA ANTI-DENGUE. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 17, 2 (Mar. 2018), 81–85. DOI:https://doi.org/10.24293/ijcpml.v17i2.1020.

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