PERAN POLIMORFISME GEN INTERFERON-g (IFNG) PADA FENOTIP HISTOLOGI NEFRITIS LUPUS

Authors

  • Kusworini Handono

DOI:

https://doi.org/10.24293/ijcpml.v17i1.1045

Keywords:

Lupus Nephritis, histological phenotype, IFNG allele

Abstract

Lupus Nephritis (LN) is a serious complication of Systemic Lupus Erythematosus (SLE) with the development of end stage renal
disease in 10–70% patients within 5 years. The condition is classified into 6 different classes according WHO criteria. Several studies
showed that there were significant clinical manifestation differences between class III, IV and class V LN. It has been suggested that the
class differences of LN was related to the cytokines balance and genetic factor. The objective of this study was to determine the role of
g-Interferron gene (IFNG) polymorphism in the class differences of LN. The study was conducted in 40 female SLE patients at the Dr.
Saiful Anwar Hospital, Malang. Histologic phenotypes classification was based on World Health Organization (WHO) criteria (1995).
Microsatelite polymorphism within the first intron of the IFNg gene on chromosome 12q24.1 was performed by DNA sequencing. The
allele difference between LN classes and healthy controle were analysed by Chi-square, the risk of LN in patients with certain IFNG allele
was calculated using Odds Ratio. The result showed that the frequency of IFNG 112 allele were higher in SLE patients compared with
healthy controls (succeptible allele) and the risk to have class V LN in patients with IFNG 112 was 6 times higher compared with patients
without these allele. There is an association between IFNG polymorphism with the LN classes.

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Submitted

2018-03-21

Accepted

2018-03-21

Published

2018-03-26

How to Cite

[1]
Handono, K. 2018. PERAN POLIMORFISME GEN INTERFERON-g (IFNG) PADA FENOTIP HISTOLOGI NEFRITIS LUPUS. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 17, 1 (Mar. 2018), 38–43. DOI:https://doi.org/10.24293/ijcpml.v17i1.1045.

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