Esti Rohani, Yetti Hernaningsih, Suprapto Ma’at, Ummi Maimunah


Liver cirrhosis remains a major clinical problem worldwide when associated with significant morbidity and mortality due to
its complications. The presence of liver cirrhosis state affects the production of TPO influencing the process of thrombopoiesis. The
thrombopoiesis activity can be described by the Immature Platelet Fraction (IPF) value which is young platelets. The immature Platelet
fraction value increases when platelet production enhances as well, on the contrary when the production declines, the IPF value is also
decreased. This study was performed by cross-sectional method using 31 subject samples suffering from liver cirrhosis, consisting of Child
Pugh score class A 2 samples (6.4%), Child Pugh score class B 9 samples (29%) and Child Pugh score class C 20 samples (64.6%). The
examination of TPO levels was done by ELISA method using Humans TPO QuantikineR, the IPF value was examined using Sysmex XE-
2100 Hematology Analyzer. The thrombopoietin serum levels in the samples ranged from 23.5 to 96.6 pg/mL with a mean of 45.1pg/mL.
The immature Platelet Fraction values varied from 1.7% to 19.1% with a mean of 6.7%. From the statistical analysis, the levels of TPO and
IPF at various degrees of the disease severity were not significantly different. There was no significant correlation between the TPO level
and IPF value, r = 0.038, p = 0.837. There was no significant difference between the TPO level and the IPF value in the splenomegaly and
nonsplenomegaly state. In conclusion, based on this study no significant correlation was found between the IPF value with thrombopoietin
serum levels, as well as the IPF and thrombopoietin levels, and there was no association with the disease severity.


Thrombopoietin, IPF, liver cirrhosis

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