EOSINOPENIA DAN PROCALCITONIN DALAM SEPSIS

Abstract

Sepsis is one of the common causes of morbidity and mortality in the ICU. Clinicians need to know and realize of good diagnostic
markers to identify sepsis as early as possible. The role of eosinopenia as a marker of sepsis has recently been evaluated.The aim of this
study was to test the value of eosinopenia as a diagnostic marker of sepsis in comparison to Procalcitonin. A cross sectional study was
performed in 61 adult patients with SIRS, and blood of all patients were cultured. Further examinations were done for comparing the
eosinophil count with the Procalcitonin levels if the blood culture was positive or when there were clinical signs which supported for sepsis.
In this study there were fourty two patients enrolled. Procalcitonin level yielded a sensitivity of 90.0%, specificity of 83.3%, a positive
predictive value (PPV) of 93.1% and a negative predictive value (NPV) of 76.9% at cut-off value of 2.75 ng/mL. The eosinophil (cut off ≤
50 cells/μL) produced a sensitivity of 80.0%, specificity of 75.0%, PPV of 88.9%, and NPV of 60.0%. based on this study Procalcitonin
appeared to be a more accurate diagnostic of sepsis than eosinopenia, but eosinopenia is still a helpful tool for clinicians, and may also be
used as a diagnostic marker of sepsis, because it is highly sensitive, moderately specific, easy to measure, rapid and inexpensive as well.