LIPOPROTEIN(a) DAN KEBAHAYAAN SINDROM KORONER AKUT

Authors

  • Ira Puspitawati
  • Setyawati Setyawati
  • Dyah Wulan Anggrahini
  • Diah Saraswati
  • Aisyah Ratna Yuniarti

DOI:

https://doi.org/10.24293/ijcpml.v21i2.1104

Keywords:

Lipoprotein(a), acute coronary syndrome, stable angina pectoris

Abstract

One of the risk factors of Acute Coronary Syndrome (ACS) still controversial is Lipoprotein(a). Lp(a) is one of the lipid components
highly homologous to plasminogen and which may compete with it in the fibrinolytic pathway and has an atherogenic effect. Prior to the
study many variaties in results have been shown. These variations are related to different population and ethnics, thus, the researchers
were triggered to investigate the role of Lp(a) on the ACS in the Indonesian population. This case control study was conducted at the
Sardjito General Hospital, Yogyakarta, Indonesia consisting of 40 participants in ACS as the case group and other 40 persons suffering
from Stable Angina Pectoris (SAP) as a control group. This study lasted from May−December 2011. The Lp(a) was measured using
turbidimetric immunoassay method while other laboratory results were obtained from the medical records. The results of this study
showed that high Lp(a) level (more than 30 mg/dL) was the risk factor of ACS (RR=2.818, CI: 1.069–7.426). There was no difference of
the baseline characteristics such as: the history of hypertension, diabetes mellitus, smoking, as well as in other laboratory parameters such
as: lipid profile, hemoglobine and uric acid level in the case as well as the control group. Significant differences were found in leucocyte
number, creatinine and blood glucose level. The median level of those parameters was found higher in the case group.

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Submitted

2018-03-27

Accepted

2018-03-27

Published

2018-03-27

How to Cite

[1]
Puspitawati, I., Setyawati, S., Anggrahini, D.W., Saraswati, D. and Yuniarti, A.R. 2018. LIPOPROTEIN(a) DAN KEBAHAYAAN SINDROM KORONER AKUT. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 21, 2 (Mar. 2018), 179–182. DOI:https://doi.org/10.24293/ijcpml.v21i2.1104.

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