ANALISIS KING'S SCORE DI PENYAKIT HATI KRONIS BERDASARKAN FIBROSCAN

Abstract

Chronic liver disease is a commonly found disease in Indonesia and remains a serious health problem. Chronic liver disease often
progresses to hepatic cirrhosis or hepatoma initiated by fibrotic process in liver. Liver biopsy result is a gold standard in determining the
liver fibrosis degree, but it has some limitations. King's Score is a non-invasive method that uses routine laboratory predictors related
to liver fibrosis. Therefore, it is necessary to know the diagnostic value of King's Score in determining the fibrosis degree of liver chronic
disease by using fibro scan as the gold standard in stead of biopsy. This study was a retrospective study with data collected from the
medical records from the Medical Record Installation at the Dr. Wahidin Sudirohusodo General Hospital between January 2011 up to
December 2013. The study results derived from 99 samples with Spearman correlation test showed a significant relationship between the
King's Score and fibrosis degree of chronic liver disease (p=0.000 and r=0.651). The analysis of the receiver operating characteristics
(ROC) indicated that in mild and moderate fibrosis the AUC value was too weak, whereas in heavy fibrosis the AUC value was 0.860,
which was statistically very strong with a cut-off value of 7.15 and with a 80.6% sensitivity, and a 75.0% specificity, Positive Predictive
Value59.5%, Negative Predictive Value 89.5%. This meant that the King's Score value of >7.15 could be used as a heavy fibrosis degree
predictor in chronic liver patients. Further studies are needed to analyze the King's Score based on chronic liver disease etiology and use
a liver biopsy as the gold standard in determining the degree of liver fibrosis.