KADAR SURFACTANT PROTEIN-D SERUM PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIS BERKEBAHAYAAN KAMBUHAN RENDAH DAN TINGGI

Authors

  • Dewi Nurhayati
  • Ida Parwati
  • Tiene Rostini
  • Arto Yuwono

DOI:

https://doi.org/10.24293/ijcpml.v22i2.1122

Keywords:

COPD, Serum SP-D level, COPD combined assessment GOLD criteria 2011, low risk of exacerbation, high risk of exacerbation

Abstract

Chronic obstructive pulmonary disease (COPD) cause high morbidity and mortality worldwide. The exacerbations in chronic
obstructive pulmonary disease accelerate the decline in lung function and health status, as well as in increasing the treatment cost and
mortality risk. The spiro metric measurement has several limitations in assessing the severity as well as the exacerbation risk in COPD
patients. Currently, has been available serum surfactant protein-D, a marker of lung inflammation and lung tissue damage. This protein
is produced by the alveolar type II cells and the Clara cells that play role in maintaining the lung stability and pulmonary immune
system. The increased level of serum SPD indicates that there is lung epitihelial leakage in line with COPD severity increment and reflected
in COPD exacerbation level of risk according to combined COPD assessment GOLD criteria of the year 2011. The aim of this study was
to know the differences of SP-D serum levels between low and high risk of exacerbation in COPD patients by determination them. This
study was conducted from March to July 2014. The subjects of this study were COPD patients diagnosed by spiro metric measurement.
The research was conducted in comparative analytic way with a cross sectional study design. The statistical analysis was performed
using Mann-Whitney non-parametric test. The subjects were 62 COPD patients. The SP-D serum level at low risk of exacerbation group
differ significantly compared to the high risk exacerbation group, 1.8–68.4 ng/mL and 3.36–116.4 ng/mL respectively (P=0.018).
Based on this study it can be concluded that the SP-D serum levels were higher in COPD patients with high risk exacerbation than the
lower risk one. The SP-D serum levels may be considered as a specific marker of lung tissue injury to assess the risk of the exacerbation
in COPD patients.

Downloads

Download data is not yet available.

Downloads

Submitted

2018-03-27

Accepted

2018-03-27

Published

2018-03-27

How to Cite

[1]
Nurhayati, D., Parwati, I., Rostini, T. and Yuwono, A. 2018. KADAR SURFACTANT PROTEIN-D SERUM PADA PASIEN PENYAKIT PARU OBSTRUKTIF KRONIS BERKEBAHAYAAN KAMBUHAN RENDAH DAN TINGGI. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 22, 2 (Mar. 2018), 168–175. DOI:https://doi.org/10.24293/ijcpml.v22i2.1122.

Issue

Section

Articles