PEMETAAN EPITOP DAN APLIKASI KLINISNYA

Abstract

Epitope mapping is one of the important findings in immunoIogy. The idea of systematic epitope mapping was first described by
Geysen et al (Geysen et al., 1987a,b). This technic is further developed together with other important findings such as monoclonal
antibody production, DNA recombinant, peptide synthesis and phage display of peptide or protein. The usage of this technic is to know the
exact binding site of antigen with antibody or T cell receptor, and can be used as the basic information to design a vaccine or diagnostic
tools. The term epitope can be further classified as functional epitope, structural epitope, binding epitope, protective epitope, heavy
infection epitope, neutralization epitope etc. In this article will be reviewed topics about epitope: B and T cell epitope mapping technics
using synthetic pin and its application.