INDEKS ATEROGENIK PLASMA DI PENYAKIT DIABETES MELITUS TIPE 2 (Atherogenic Index of Plasma in Type 2 Diabetes Mellitus)

Amarensi M Betaubun, Uleng Bahrun, Ruland Pakasi

Abstract


Atherogenic Index of Plasma (AIP) as a new marker of atherogenicity and directly related to the risk of atherosclerosis, is a simple
and inexpensive method to assess the severity of atherogenic dyslipidemia. 97% of adult patients with type 2 DM (T2DM) will have
dyslipidemia including increased levels of TG, low HDL-C levels whereas LDL cholesterol levels had no effect. To determine the atherogenic
index of plasma in controlled and uncontrolled T2DM. A Cross-sectional study was conducted on 72 controlled T2DM samples and 112
uncontrolled T2DM samples from Clinic of Endocrine and Methabolic dr Wahidin Sudirohusodo Hospital Makassar, starting from April-
May 2013. Fasting glucose level, triglycerides, HDL-C and HbA1c determined using ABX Pentra 400 (colorimetric method). Data then
analyzed with Mann Withney U test. Most of the samples are male, with the age range from 51-60 years old. Mean AIP is not so different
between the two groups (0.51±0.28 and 0.55±0.28 respectively). Fasting glucose level, triglycerides, HDL-C in T2DM uncontrolled were
higher than controlled. The atherogenic index of plasma of controlled T2DM group were 0.93 times lower than uncontrolled T2DM, Mann
Withney U test showed that there were no significant correlation between both of group (p>0.05). Atherogenic index of plasma cannot
be used to distinguish between controlled and uncontrolled T2DM.


Keywords


Atherogenic index of plasma, log (TG/HDL-C), type 2 diabetes mellitus

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DOI: http://dx.doi.org/10.24293/ijcpml.v22i1.1228

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