OXIDIZED-LOW DENSITY LIPOPROTEIN DAN DERAJAT STENOSIS PENYAKIT JANTUNG KORONER (Oxidized-Low Density Lipoprotein and Stenosis Level in Coronary Artery Disease)

Abstract

Coronary artery disease is caused by atherosclerosis of the coronary arteries. Ox-LDL plays a role in atherosclerosis causing coronary
artery stenosis. There are differences in the research results on the relationship of ox-LDL levels and stenosis level of coronary artery
in patients with CAD. The aim of this study was to know the correlation between ox-LDL and stenosis level of coronary artery in
Coronary Artery Disease (CAD). An observational study with cross sectional analytic approach was conducted on 37 patients with CAD
who underwent coronary angiography in the Dr. Kariadi General Hospital and Telogorejo Hospital of Semarang, taken consecutively
during Febuary up to April 2014. The Ox-LDL levels were determined by sandwich ELISA and the stenosis levels were determined by
coronary angiography. The data were analyzed by non-parametric Spearman correlation test. Median of ox-LDL level in CAD patients
was 1666.8(846.15; 3324) pg/mL. The median of stenosis level was 80 (30;90)%. There was a significant correlation of ox-LDL level
and stenosis level (r=0.358; p=0.03) in CAD patients. Based on this study there was a weak positive correlation between ox-LDL level
and stenosis level in CAD patients.