D-DIMER AND FIBRINOGEN IN PATIENTS UNDERWENT SURGERY IN MALIGNANT AND BENIGN OVARIAN TUMOR (D-Dimer Dan Fibrinogen Pada Pasien-Pasien Yang Menjalani Tindakan Pembedahan Pada Tumor Ovarium Ganas Dan Jinak)

Ismail Aswin, Herman Hariman, Fauzie Sahil

Abstract


Ovarian tumour ranks second in gynecology tumour cases and ranks second in gynecology tumour death in Indonesia. Tumour cause hypercoagulable that increase risk of thrombosis by procoagulant mechanism. Tumout cells also can cause hyperfibrinogenemmia that can cause bleeding. The aim of study was to know D-dimer and fibrinogen value to investigate primary hyperfibrinolysis on malignant and benign ovarian tumour; and to know whether operation procedure on malignant and benign tumour change D-dimer and fibrinogen value. Prospective analysis study, subject were malignant and benign ovarian tumour patients undergoing surgery in Haji Adam Malik Hospital, Medan. One way Annova test dan Wilcoxon Sum-Rank test were performed. Stastical differentiation is indicate with p<0,05. Study subject was 16 patient where 8 malignant and benign ovarian tumour patient respectively. Malignant ovarian tumour D-dimer values was higher than benign ovarian tumour (p<0,01) that indicate fibrinolysis increase in malignant ovarian tumour. Malignant ovarian tumour fibrinogen values as same as benign ovarian tumour (p>0,05) that indicate the fibrinolysis in ovarian tumour wasn’t primary hyperfibrinolysis. Surgery procedure didn’t influence D-dimer and fibrinogen values. Primary hyperfibrinolysis wasn’t occur in ovarian tumour.

Keywords : Ovarian tumour, malignant, benign, D-dimer, fibrinogen.


Keywords


D-dimer;fibrinogen;ovarian tumor

Full Text:

PDF

References


Maharana S, Suraneni PD. A Histopathological study of benign ovarian tumos. MRIMS Journal of Health Sciences 2015;3(2)

Niekerk CC, Bulten J, Dijck JAAM, Verbeek ALM. Epithelial Ovarian Carcinoma Types and the Coexistence of Ovarian Tumor Conditions. ISRN Obstetrics and Gynecology Volume 2011.

Sitalakshmi S, Rameshkumar K, Damodar P. Significance of Haemostatic Markers in Ovarian Carcinoma. Indian Journal Of Medical & Paediatric Oncology. 2008;Vol. 29 No 2.

Filimonovic JD, Tulic C, Dzamic Z, et.al. Elevated plasma D-dimer as a predictor of

postoperative complications after radical cystectomy. ACI Vol. LIV

Palumbo JS, Kombrinck KW, Drew AF, et.al. Fibrinogen is an important determinant of the metastatic potential of circulating tumor cells. BLOOD, 15 November 2000 z Volume 96, Number 10.

Ahammed AAE, Khalil HBE. Assessment Of D. Dimer Level For Pre And

Post-Surgical Operation Patients. Journal of Science / Vol 5/ Issue 12 / 2015 / 1309-1312.

Gerlach R, Tolle F, Raabe A, et.al. Increased Risk for Postoperative Hemorrhage After Intracranial Surgery in Patients With Decreased Factor XIII Activity. Implications of a Prospective Study. Stroke. 2002;33:1618-1623.

Prat J. FIGO’s staging classifcation for cancer of the ovary, fallopian tube, and peritoneum: abridged republication. J Gynecol Oncol Vol. 26, No. 2:87-89

Lengyel E. Ovarian Cancer Development and Metastasis. The American Journal of Pathology. September 2010; Vol. 177, No. 3.

Wang X, Wang A, Kavanagh, et.al. Ovarian cancer, the coagulation pathway, and inflammation. Journal of Translational Medicine 2005, 3:25.

Falanga A, Marchetti M, Vignoli A. Coagulation and cancer: biological and clinical aspects. Journal of Thrombosis and Haemostasis, 11: 223–233

Khorana AA. Cancer-associated thrombosis: updates and controversies. Hematology.2012

Beleva E, Grudeva-Popova J. From Virchow’s triad to metastasis: circulating hemostatic factors as predictors of risk for metastasis in solid tumors. J BUON 2013; 18(1): 25-33

Adam SS, Key NS, Greenberg CS. D-dimer antigen: current concepts and future prospects. Blood. 2009; 113:2878-2887

Kawaguchi R, Furukawa N, Kobayashi H. Cut-off value of D-dimer for prediction of deep venous thrombosis before treatment in ovarian cancer. J Gynecol Oncol Vol. 23, No. 2:98-102

Polterauer S, Grimm C, Seebacher V, et.al. Plasma Fibrinogen Levels and Prognosis in Patients with Ovarian Cancer: A Multicenter Study. The Oncologist 2009;14:979–985

Lu D-Y, Chen X-L, Gao J-y, et.al. Effects of Cancer Chemotherapy on the Blood Fibrinogen Concentrations of Cancer Patients. The Journal of International Medical Research. 2000; 28: 313-317

Dindo D, Breitenstein S, Hahnloser D, et.al. Kinetics of D-dimer after general surgery. Coagul Fibrinolysis 20:347–352

Kodama J, Seki N, Fukushima C, et.al. Postoperative decreased levels of D dimer in patients with gynecologic cancer with enoxaparin and fondaparinux thromboprophylaxis. Molecular And Clinical Oncology. 2013; 1: 737-744

Prell J, Rachinger J, Smaczny R, et.al. D-dimer plasma level: a reliable marker for venous thromboembolism after elective craniotomy. J Neurosurg.2013;119:1340–1346.

Ruiz-Sada P, Nahia A, Iker G, et.al. Primary Hyperfibrinolysis as a Presentation of Extended Prostate Carcinoma. ROM. J. INTERN. MED., 2016, 54, 3, 191–193




DOI: http://dx.doi.org/10.24293/ijcpml.v25i2.1288

Refbacks

  • There are currently no refbacks.