CORRELATION BETWEEN PLATELET TO LYMPHOCYTE RATIO AND CORONARY ARTERY NARROWING

Authors

  • Enny Marziah Department of Clinical Pathology, Faculty of Medicine, Sumatera Utara University/Adam Malik Hospital, Medan, Indonesia
  • Adi Koesoema Aman Department of Clinical Pathology, Faculty of Medicine, Sumatera Utara University/Adam Malik Hospital, Medan, Indonesia
  • Andre Pasha Ketaren Department of Cardiology, and Vascular Medicine, Faculty of Medicine Sumatera Utara University/Adam Malik Hospital, Medan

DOI:

https://doi.org/10.24293/ijcpml.v24i3.1331

Keywords:

Coronary heart disease, platelet to lymphocyte ratio, coronary artery narrowing

Abstract

Coronary Heart Disease (CHD) is one of the most common diseases of the cardiovascular system, characterized by atherosclerotic lesions. Atherosclerotic vascular processes are multifactorial. One of the factors is the process of inflammation. Platelet to Lymphocyte Ratio (PLR) is a marker that predicts the atherosclerotic coronary burden. The purpose of this research was to determine the correlation between platelet to lymphocyte ratio and coronary artery narrowing in CHD patients. This research was an analytical observation with a cross-sectional design, conducted on 54 patients with CHD who underwent angiography at the Adam Malik Hospital, Medan in February–October 2016. We examined platelet count, absolute lymphocyte count and percentage of coronary artery narrowing and coronary artery narrowing in CHD patients. There is a weak correlation between platelet to lymphocyte ratio and coronary artery narrowing in CHD patients ((r=0.276)). The result of the statistic test showed no significant correlation of platelet to lymphocyte ratio and coronary artery narrowing patients (p=0.043). In this study there is a weak correlation between platelet to lymphocyte ratio and coronary artery narrowing in CHD patients.

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References

Min JK. Coronary CTA versus cardiac catheterization: Where do we stand today? Well Medical College of Cornell University. New York, Presbyterian Hospital, 2006; 32-40.

Smith RA, Ghaneh P, Sutton R, Raraty M, Campbell F, Neoptolemos JP. Prognosis of resected ampullary adenocarcinoma by preoperative serum CA19-9 levels and platelet-lymphocyte ratio. J Gastrointest Surg, 2008; 12(8): 1422-8.

Alwi I, Setiati S, Sudoyo Aru W, M. Simadibrata, B. Setyohadi, Dkk. Ilmu penyakit dalam, Jakarta, Internal Publishing, 2014; 1292-1293.

Libby P, Bonow RO, Mann DL. Braunwald's heart disease: A textbook of cardiovascular medicine. 8th Ed, Philadelphia, 2007; 402-419.

Alwi Idrus. Hanafi Muin Rahman, S Harun. Ilmu penyakit dalam jilid III. Penyadapan jantung (Cardiac Catheterization) Jakarta, FKUI 2006; 1491-496.

Departemen Kesehatan RI. Penyakit tidak menular. In: Buletin jendela dan data kesehatan, ISSN 2088-207X. Jakarta, Bakti Husada, 2012; 1-11.

Gary T, Pichler M, Belaj K, Hafner F, Gerger A, et al. Platelet-to-lymphocyte ratio: A novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. Plos One, 2013; 8(7): e67688.

Watson K. CHD Based upon the more stringent guidelines of ATP III, as compared to ATP II, a more aggressive treatment strategy is warranted in dyslipidemia patient, advanced studies in medicine, JAMA, 2001; 285: 2486-2497.

Nikolsky E. Grines CL, Cox DA. Impact of baseline platelet count in patients undergoing primary percutaneous coronary intervention in acute myocardial infarction (from the CADILLAC trial). Am J Cardiol, 2007; 99: 1055-61.

Zouridakis EG, Garcia-Moll X, Kaski JC. Usefulness of the blood lymphocyte count in predicting recurrent instability and death in patients with unstable angina pectoris. Am J Cardiol, 2000; 86(4): 449-51.

Proctor MJ, Morrison DS, Talwar D, Balmer SM, Fletcher CD, O'Reilly DS, Foulis AK, Horgan PG, McMillan DC, et al. A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow inflammation outcome study. Eur J Cancer, 2011; 47: 2633-41.

Yüksel M, Yıldız A, Oylumlu Mustafa. The association between platelet/lymphocyte ratio and coronary artery disease severity. Department of Cardiology, Faculty of Medicine, Dicle University, Diyarbakir_Turkey, Anatol J cardiol. 2015; 15(8): 640-647.

Thaulow E, Erikssen J, Sandvik L, Stormorken H, Cohn PF. Blood platelet count and function are related to total and cardiovascular death in apparently healthy men. Circulation, 1991; 84: 613-7.

Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation, 2005; 92: 657-67.

Madjid M, Fatemi O. Component of the complete blood count as risk predictor for coronary heart disease. Text Heart Inst J 2013; 40(1): 17-29.

Khandekar MM, Khurana AS, Deshmukh SD, Kakrani AL, Katdare AD, Inamdar AK. Platelet volume indices in patients with coronary artery disease and acute myocardial infarction: An Indian scena. J Clin Pathol. 2006; 59(2): 146–149.

Azab B, Shah N, Akerman M. Value of platelet/lymphocyte ratio as a predictor of all-cause mortality after non-STelevation myocardial infarction. J Thromb Thrombolysis, 2012; 34(3): 326-34.

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Submitted

2018-11-02

Accepted

2018-12-03

Published

2018-07-01

How to Cite

[1]
Marziah, E., Aman, A.K. and Ketaren, A.P. 2018. CORRELATION BETWEEN PLATELET TO LYMPHOCYTE RATIO AND CORONARY ARTERY NARROWING. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 24, 3 (Jul. 2018), 219–222. DOI:https://doi.org/10.24293/ijcpml.v24i3.1331.

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