ASSOCIATION BETWEEN SPESIFIC ENOLASE SERUM LEVELS AND OUTCOME ACUTE ISCHEMIC STROKE ONSET 1-MONTH
DOI:
https://doi.org/10.24293/ijcpml.v25i2.1377Keywords:
Neurons specific enolase, ischemic stroke, outcomeAbstract
Pendahuluan: Stroke adalah masalah kesehatan global, karena penyebab kematian kedua dan kecacatan utama pada hampir seluruh negara di dunia. Penyakit ini memiliki dampak yang besar terhadap penderita, lingkungan sosial dan beban ekonomi. Sehingga diperlukan penanda spesifik yang berperan dalam menegakkan diagnosis, penentuan faktor risiko, serta tingkat keparahan stroke iskemik. Salah satu penanda yang diteliti adalah kadar NSE serum, yang diperkirakan dapat menggambarkan beratnya kerusakan otak pada pasien stroke.
Metode: Penelitian ini menggunakan metode Cross sectional study pada 77 pasien stroke iskemik , dilaksanakan mulai Juli 2016 sampai Agustus 2017, di ruang rawat inap di Bagian Penyakit Saraf RS. DR. M. Djamil Padang. Setiap pasien dilakukan pemeriksaan kadar NSE serum dan penilaian skor mRS pada bulan-1 setelah onset stroke iskemik. Dan dilakukan uji Spearmen untuk menilai korelasi antara dua variabel. Nilai p <0.05 dianggap signifikan secara statistik
Hasil: Berdasarkan jenis kelamin didapatkan laki-laki 42 orang (54.54%). Median usia 58.21 (16-88). Median kadar NSE 5.94 ( 2.77-36.75) µg/L. Skor mRS onset bulan-1 dengan median 3 (1-6). Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1 (r = 0.286, p value= 0.012, R2= +8.2%)
Diskusi: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.
Kesimpulan: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.
Downloads
References
Thrift AG, Cadhilhac D, Thayabaranathan T, Howard G, Howard V, et al. Global stroke statistics. International Journal of stroke.2013. vol. 9: pp 6-18.
KrishnamurthiR, Moran A, FeiginV., Barker-CS, NorrvingB,et al. Stroke Prevalence, Mortality and Disability-Adjusted Life Years in Adults Aged 20-64 Years in 1990-2013: Data from the Global Burden of Disease 2013 Study. Neuroepidemiology. 2015;45(3): pp.190-202.
Whiteley W, Li CW, Sengupta A, andSandercock P. Blood Markers for the Prognosis of Ischemic Stroke, a systemic review. Stroke. 2009;40: e380-e389
RondriguezYM, Sobrino T, Aria S, VazquezHF, Brea D, et al. Early Biomarkers of clinical -Diffusion Mismatch in Acute Ischemic Stroke. Stroke.2011;42: 2813-2818.
Antonietta IM, Bottoni P,and Scatena R. Neuron- Specific Enolase as a Biomarker: Biochemical and clinical Aspects. Springers Science. 2015; 98-110
Wu YC, Zhao YB, Lu CZ, Qiao J, andTan YJ. Correlation between serum level of neuron-specific enolase and long-term functional outcome after acute cerebral infarction: prospective study. Hong Kong Med J.2004;10: 251-4.
Stanca DM, Marginean IC, Soritau O, and Muresanu DF. Plasmatic Markers for early diagnostic and treatment decisions in ischemic stroke. Journal of medicine and life vol 8, Special Issue, 2015; pp 21-25.
Prasad BO, Tiwari S, andUsman K.Role of serum Neuron Specific Enolase in differentiating the side of brain lesion in acute ischemic stroke. International Journal of Biomedical Research. 2015;6(08): 570-573
Brouns R, De V, De SD, Marien P, andDe DP.Neurobiochemical Markers of Brain Damage in cerebrospinal fluid of Acute Ischemic Stroke Patients. Clinical Chemistry. 2010;56: pp 451-458.
Komariah N, Setyawati,and Usi S. Korelasi Neuron Spesific Enolase (NSE) serum dengan kejadian perburukan pada pasien stroke iskemik akut. Thesis. 2011
Ahmad O, Wardlaw JandWhiteley W. Correlation of Levels of Neuronal and Glial Markers with Radiological Measures of Infarct Volume in Ischaemic Stroke: A systemic Review. Cerebrovasc Dis, 2012; 33.pp 47-54.
Padalkar R, Sangita P, Sonali B, Rhul G, andDhananjay A. Study of Neuron-Specific Enolase as Potential Biomarker for assessing the severity and outcome in patients with Cerebrovascular Accidents. Global Journal of Medical Research. 2014; volume 14
Missler U, Wiesmann M, Friedrich C, and Kaps M. S-100 protein and neuron specific enolase concentrations in blood as indicators of infarction volume and prognosis in acute ischemic stroke. Stroke,1997; 28:1956–60.
Kaca-Orynska M, Tomasiuk R, andFriedman A. Neuron Specific enolase and S 100B protein as predictors of outcome in ischaemic stroke. Neurologia i Neurochirurgia Polska. 2010;44(5): 459-463.
Altunayoglu V, Gunduz A, Karaca Y, Alioglu Z, Mentese A, et al.Diagnostic Significance of Ischemia-modified Albumin, S100b, and Neuron- Specific Enolase in Acute Ischemic Stroke. JAEM 2014; 13: 112-7.
Rosamond W, Flegal, K, Friday, G, Furie, K, Go, Alan, et al. Heart Disesase and Stroke Statistics-2007 Update: A Report From the American Heart Assotiation Statistic Committee and Stroke Statistics Subcommitte. Circulation. 2007;115: 69-171.
Brea D, Sobrino T, Blanco M, Cristobo I, RondriguezGR, et al. Temporal profile and clinical significance of serum neuron-specific enolase and S 100 in ischemic and hemorrhagic stroke. Clin Chem Lab Med. 2009;47(12): 1513-1518.
O'Donnell, M., Xavier, D., Liu, L., Zhang, H., Chin, S.et al. Risk factors for ischaemic and intracerebral haemorrhagic stroke in 22 countries (the INTERSTROKE study): a case-control study. The Lancet, 2010; 376(9735), pp.112-123.
Ritzel R, Capozzi L and McCullough L. Sex, stroke and inflammation; the potential for estrogen-mediated immunoprotection in stroke. Hormones and Behavior, 2013;63(2);pp.238-253
Casmiro M, Maitan S, De Pasquale, Cova V, Scarpa E, et al. Cerebrospinal fluid and serum neuron-specific enolase concentrations in normal population. European Journal of Neurology.12; 2005: 369-374.
Cunningham RT, Young IS, and Winder J, et al.Serum neuron-specific enolase (NSE) levels as an indicator of neuronal damage in patients with cerebral infarction. Eur J Clin Invest, 1996;32:497–500.
Downloads
Submitted
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.