ASSOCIATION BETWEEN SPESIFIC ENOLASE SERUM LEVELS AND OUTCOME ACUTE ISCHEMIC STROKE ONSET 1-MONTH

Authors

  • Yuri Haiga Department of Neurology, Andalas University, Padang, Indonesia
  • Darwin Amir Department of Neurology, Andalas University,Padang, Indonesia
  • Yuliarni Syafrita Department of Neurology, Dr.M.Djamil Hospital, Padang, Indonesia

DOI:

https://doi.org/10.24293/ijcpml.v25i2.1377

Keywords:

Neurons specific enolase, ischemic stroke, outcome

Abstract

Pendahuluan: Stroke adalah masalah kesehatan global, karena penyebab kematian kedua dan kecacatan utama pada hampir seluruh negara di dunia. Penyakit ini memiliki dampak yang besar terhadap penderita, lingkungan sosial dan beban ekonomi. Sehingga diperlukan penanda spesifik yang berperan dalam menegakkan diagnosis, penentuan faktor risiko, serta tingkat keparahan stroke iskemik. Salah satu penanda yang diteliti adalah kadar NSE serum, yang diperkirakan dapat menggambarkan beratnya kerusakan otak pada pasien stroke.

Metode: Penelitian ini menggunakan metode Cross sectional study pada 77 pasien stroke iskemik , dilaksanakan mulai Juli 2016 sampai Agustus 2017, di ruang rawat inap di Bagian Penyakit Saraf RS. DR. M. Djamil Padang. Setiap pasien dilakukan pemeriksaan kadar NSE serum dan  penilaian skor mRS pada bulan-1 setelah onset stroke iskemik. Dan dilakukan uji Spearmen untuk menilai korelasi antara dua variabel. Nilai p <0.05 dianggap signifikan secara statistik

Hasil: Berdasarkan jenis kelamin didapatkan laki-laki 42 orang (54.54%).  Median  usia 58.21 (16-88). Median kadar NSE  5.94 ( 2.77-36.75) µg/L. Skor  mRS onset bulan-1 dengan  median 3 (1-6). Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1 (r = 0.286, p value= 0.012, R2= +8.2%)

Diskusi: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.

Kesimpulan: Terdapat hubungan antara kadar serum NSE dengan fungsi luaran stroke iskemik onset bulan-1.

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Author Biographies

Yuri Haiga, Department of Neurology, Andalas University, Padang, Indonesia

Bagian Ilmu Penyakit Saraf, Fakultas Kedokteran, Universitas Andalas,
Padang, Indonesia

Darwin Amir, Department of Neurology, Andalas University,Padang, Indonesia

Program Studi Pendidikan Dokter Spesialis Saraf, Fakultas Kedokteran, Universitas Andalas, Padang, Indonesia

Yuliarni Syafrita, Department of Neurology, Dr.M.Djamil Hospital, Padang, Indonesia

Ruang Rawat Inap, Bagian Ilmu Penyakit Saraf, RSUP DR.M.Djamil, Padang, Indonesia

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Submitted

2018-11-27

Published

2019-04-13

How to Cite

[1]
Haiga, Y., Amir, D. and Syafrita, Y. 2019. ASSOCIATION BETWEEN SPESIFIC ENOLASE SERUM LEVELS AND OUTCOME ACUTE ISCHEMIC STROKE ONSET 1-MONTH. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 25, 2 (Apr. 2019), 135–139. DOI:https://doi.org/10.24293/ijcpml.v25i2.1377.

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