THE DEGREE OF LIVER FIBROSIS ANALYSIS WITH APRI SCORE AND FIB4 INDEX ON PATIENTS WITH NON-ALCOHOLIC FATTY LIVER

Gillian Elvira Seipalla, Nurahmi Nurahmi, Ibrahim Abd Samad

Abstract


Background - Liver fibrosis is the accumulation of extracellular matrix protein (MES) scar tissue after acute or chronic liver injury. Liver biopsy is the gold standard method for evaluating liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). This diagnostic method is invasive, painful, and complicated in rare cases, hence the noninvasive method like laboratory tests and radiology had been proposed to assess liver fibrosis in NAFLD and can overcome the limitations of liver biopsy. This method consists of aspartate aminotransferase to platelet index ratio (APRI) and fibrosis 4 (FIB-4).

Methods - This retrospective cross sectional study was conducted at Wahidin Sudirohusodo Hospital Makassar by taking a total sample of 63 people from January to June 2018. The correlated variables were made in categorical and numerical using Pearson Correlation statistical test, to assess the compatibility of APRI Score and FIB4 Index with Fibroscan result in patients with NAFLD.

Results - A highly significant positive correlation (p <0.001) was found between APRI score and fibroscan (correlation value = 45,8%), APRI Score and FIB4 index (correlation value = 91,8%), FIB4 index and fibroscan (correlation value = 47,6%).

Conclusion - APRI Score and FIB-4 Index can be an alternative method instead of liver biopsy to predict the degree of fibrosis in patients with NAFLD.


Keywords


Liver Fibrosis, APRI Score, FIB4 Index.

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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1414

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