CORRELATION BETWEEN PLASMA OSTEOPONTIN AND ALKALINE PHOSPHATASE IN TYPE 2 DIABETES MELLITUS PATIENTS

josua togu hamonangan sinambela

Abstract


Background: Diabetes mellitus (DM) is a chronic disease caused by pancreas inability to produce insulin or ineffectively used insulin. Fracture risk in type 2 DM patients increases even though the bone density is normal. This study aimed to examine the correlation of osteopontin (OPN) and alkaline phosphatase (ALP) in type 2 DM patientsMethods: Observational analytical study was conducted in 73 type 2 DM patients in Dr. Moewardi hospital Surakarta from October to November 2018. The subjects were examined for blood pressure, fasting blood glucose, 2 hours after meals blood glucose, HbA1c, OPN and ALP levels. p value <0.05 was statistically significant with 95% confidence intervalResults: Poorly controlled type 2 DM had higher OPN levels than well controlled (20.5 ± 2.8 vs 14.8 ± 3.1 ng/ml, p <0.001). ALP concentration were also higher in poorly controlled type 2 DM patients (79.9 ± 31.7 vs 61.1 ± 25 U / L, p=0.003). The levels of OPN and ALP were significantly correlated in type 2 diabetes (r=0.273; p=0.020) and in well controlled patients (r=0.353; p=0.047) but no correlation was found in poorly controlled type 2 DM patients (r= -0,073; p= 0,652)Conclusion: In our study we found a significant correlation between OPN and ALP in patients with type 2 DM and well controlled. Further study involving healthy control and bone ALP measurement is needed

Keywords


Type 2 diabetes mellitus, OPN, ALP

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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1468

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