Analysis of D-dimer Levels in Deep Vein Thrombosis Patients

Anton Triyadi, Rachmawati A. Muhiddin, Agus Alim Abdullah

Abstract


It is reported the incidence of DVT is approximately 84 cases per 100,000 each year, with 30-50% of untreated DVT are at
risk for pulmonary embolism, causing a 12% increase in mortality rate. An accurate and rapid diagnosis of DVT is needed to
minimize the risk of complications and prevent unnecessary anticoagulant therapy without waiting for the results of a
diagnostic examination using ultrasound. This study aimed to determine the diagnostic value of plasma D-dimer levels on
Doppler ultrasound for DVT diagnosis to help clinicians to select a rapid and accurate diagnostic test for DVT diagnosis. This
research was a retrospective study using data from medical records and performed at the Medical Record Installation of Dr.
Wahidin Sudirohusodo Hospital, Makassar, by taking data on patients with DVT along with the results of D-dimer and
Doppler ultrasound from January to December 2018. D-dimer levels were measured using an immunoturbidimetric method
with a reference value of<0.5 μg/mL. A total of 33 samples were obtained with a mean of D-dimer value was higher in
positive Doppler (5.29) compared to negative (2.31), although not statistically significant (p> 0.05). Also, the mean of Wells
score was higher in positive Doppler (4.74) compared to negative (4.17), although not statistically significant (p> 0.05). The
diagnostic values of D-dimer were as follows: sensitivity of 92.6%, specificity of 33.3%, positive predictive value of 86.2%,
negative predictive value of 50.0%, and accuracy of 81.8%. D-dimer test can be used both for screening and diagnostic tests
with cut-off value ≥ 2 μg/mL.


Keywords


Deep vein thrombosis, D-dimer, Doppler ultrasound

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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1531

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