The Correlation between Serum Growth Differentiation Factor-15 Levels and Post-Acute Myocardial Infarction Acute Heart

Authors

  • Kenny Mayavani Cllnical Pathology of Sebelas Maret University Surakarta
  • JB. Suparyatmo Cllnical Pathology of Sebelas Maret University Surakarta
  • Dian Ariningrum Cllnical Pathology of Sebelas Maret University Surakarta

DOI:

https://doi.org/10.24293/ijcpml.v26i3.1555

Keywords:

Acute myocardial infarction, GDF-15, hypertension history, acute heart failure

Abstract

Acute Heart Failure (AHF) is a common rapid complication of Acute Myocardial Infarction (AMI). Myocardial dysfunction leads to pathologic remodeling of the heart, which causes AHF. Growth differentiation factor-15 (GDF-15) is expressed by cardiomyocytes and upregulated due to injury and cardiomyocyte damage. Thus, it can be used as a predictor of severe heart damage. This study aimed to determine the correlation between GDF-15 levels and the incidence rate of post-AMI AHF. This prospective cohort study was performed in patients with AMI treated in Dr. Moewardi Hospital from August to September 2019. The Kolmogorov-Smirnov normality test was used. Bivariate analysis was applied for Hazard Ratio (HR) with 95% CI. The GDF-15 cut-off used the ROC curve. The Cox Regression Proportional Hazard Model was used for multivariable analysis. The significance value was p <0.05. During the study, there were a total of 74 subjects. Bivariate analysis showed significant correlation between serum GDF-15 levels and hypertension history to the incidence of post-AMI AHF [HR=3.259; 95%CI (1.1558–6.819); p=0.002] and [HR=3.293; 95%CI (1.489-7.282); p=0.003]. Multivariate analysis showed that both variables had a similar strength of the correlation. The risk and the incidence rate of AHF were three times higher in AMI subjects with a history of hypertension and elevated GDF-15 levels. High serum GDF-15 levels and a history of hypertension can be predictors of post-AMI AHF.

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Author Biographies

Kenny Mayavani, Cllnical Pathology of Sebelas Maret University Surakarta

Cllnical Pathology of Sebelas Maret University Surakarta

JB. Suparyatmo, Cllnical Pathology of Sebelas Maret University Surakarta

Cllnical Pathology of Sebelas Maret University Surakarta

Dian Ariningrum, Cllnical Pathology of Sebelas Maret University Surakarta

Cllnical Pathology of Sebelas Maret University Surakarta

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Submitted

2019-10-18

Accepted

2020-04-30

Published

2020-09-30

How to Cite

[1]
Mayavani, K., Suparyatmo, J. and Ariningrum, D. 2020. The Correlation between Serum Growth Differentiation Factor-15 Levels and Post-Acute Myocardial Infarction Acute Heart. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 26, 3 (Sep. 2020), 312–316. DOI:https://doi.org/10.24293/ijcpml.v26i3.1555.

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