Antibiotics Susceptibility Pattern of MRSA at Intensive Care Room of Ulin General Hospital Banjarmasin

Authors

  • Shania Indah Chineko Medical Education Study Program, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin
  • Dewi Indah Noviana Pratiwi Department of Clinical Pathology, Faculty of Medicine, Lambung Mangkurat University/Ulin General Hospital, Banjarmasin
  • Rahmiati Rahmiati Microbiology Division, Department of Microbiology-Parasitology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin
  • Noor Muthmainnah Microbiology Division, Department of Microbiology-Parasitology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin
  • Alfi Yasmina Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

DOI:

https://doi.org/10.24293/ijcpml.v27i2.1649

Keywords:

Methicillin-resistant Staphylococcus aureus, susceptibility, antibiotics, intensive care room

Abstract

Infection caused by Methicillin-Resistant Staphylococcus aureus (MRSA) is a healthcare-associated infection that receives the most significant attention worldwide due to its resistance. Administration of precise and rational antibiotics can prevent high MRSA rates in hospitals. This study aimed to determine the antibiotic susceptibility pattern of MRSA at the intensive care room of Ulin General Hospital, Banjarmasin, between 2016 and 2018. This study was an observational analytic study by taking the results of culture and antibiotic susceptibility pattern data of the MRSA isolated from patients treated at the intensive care room retrospectively. The results showed 37 data of patients suffering from MRSA at the intensive care room in 2016-2018, with a percentage of 23.81%, 25.81%, and 35.19%, respectively. The most common sources of MRSA isolate in this study were sputum (32.39%), blood (29.27%), and pus (16.67%). From 2016 to 2017, there was a decreased susceptibility to macrolide antibiotics, aminoglycosides such as Gentamicin, and quinolones such as Moxifloxacin. In 2018, there was an increased susceptibility pattern of some antibiotics compared to the previous period. Antibiotics with the highest susceptibility in period of 2016-2018 were Linezolid, Quinupristin/Dalfopristin, Tigecycline, Nitrofurantoin, and Trimethoprim/Sulfamethoxazole. Also, the antibiotic with the lowest susceptibility was Tetracycline. It was concluded that there had been changes in some antibiotics' susceptibility pattern to MRSA within 2016-2018.

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Author Biographies

Shania Indah Chineko, Medical Education Study Program, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Medical Education Study Program, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Dewi Indah Noviana Pratiwi, Department of Clinical Pathology, Faculty of Medicine, Lambung Mangkurat University/Ulin General Hospital, Banjarmasin

Department of Clinical Pathology, Faculty of Medicine, Lambung Mangkurat University/Ulin General Hospital, Banjarmasin

Rahmiati Rahmiati, Microbiology Division, Department of Microbiology-Parasitology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Microbiology Division, Department of Microbiology-Parasitology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Noor Muthmainnah, Microbiology Division, Department of Microbiology-Parasitology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Microbiology Division, Department of Microbiology-Parasitology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Alfi Yasmina, Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

Department of Pharmacology, Faculty of Medicine, Lambung Mangkurat University, Banjarmasin

References

Kurniawati AFS. Satyabakti P, Arbianti N. Perbedaan risiko Multidrug-Resistance Organisms (MDROS)

menurut faktor risiko dan kepatuhan hand hygiene. Jurnal Berkala Epidemiologi, 2015; 3(3): 277-89.

Prasetio M, Berliana, Melisa I. Article review: Gen mecA sebagai faktor munculnya MRSA. Bandung, Fakultas Farmasi Universitas Padjadjaran, 2017; 14(3): 53-61.

Pratiwi DIN. Pola kuman dan sensitivitas antibiotik di RSUD Ulin Banjarmasin. Banjarmasin, Divisi Infeksi Bag Patologi Klinik RSUD Ulin Banjarmasin. 2015; 1-70.

Oliphant CM, Catherine M, Eroschenko K. Antibiotic resistance part 1: Gram-positive pathogens. American Association of Nurse Practitioners. USA, Elsevier, 2015; 11(1): 70-8.

Dewi YP. Tren perubahan pola kuman dan sensitivitas antimikroba dari isolat darah di unit perawatan

intensif RSUP Dr. Sardjito Yogyakarta 2008-2012.

Yogyakarta, Fakultas Kedokteran Universitas Gadjah Mada, 2015; 1-19.

Asri RC, Rasyid R. Identifikasi MRSA pada diafragma stetoskop di ruang rawat inap & HCU bagian penyakit dalam. Jurnal Kesehatan Andalas, 2017; 6(2): 239-44.

Nasional Republika. Sholikah B, Putri WD. Angka kasus MRSA meningkat. Tersedia dari: https://nasional.republika.co.id/berita/nasional/umum/17/01/19/ojzjvy359-angka-kasus-mrsa-meningkat (accessed 26 November, 2019).

Nuryah A, Yuniarti N, Puspitasari I. Prevalensi dan evaluasi kesesuaian penggunaan antibiotik pada

pasien dengan infeksi MRSA di RSUP Dr. Soeradji Tirtonegoro Klaten. Majalah Farmaseutik, 2019; 15(2):

-9.

Budiman HM, Soleha TU, Warganegara E, Anggraini DI. Prevalensi kolonisasi bakteri MRSA di ruang

Intensive Care Unit (ICU) Rumah Sakit Umum Daerah Abdul Moeloek Bandar Lampung. Majority, 2020; 9(1): 19-23.

Huang H, Ran J, Yang J, Li P, Zhuang G. Impact of MRSA and infection in a neonatal intensive care unit in China: A bundle intervention study during 2014-2017. BioMed Research International, 2019: 1-7.

Sampedro GR, Wardenburg JB. Staphylococcus aureus in the intensive care unit: Are these golden

grapes ripe for new approach?. The Journal of Infectious Diseases, 2017; 215: 1–7.

Nasution GS. Deteksi gen resisten mecA pada isolat bakteri Staphylococcus aureus yang tergolong MRSA dari hasil pemeriksaan Vitek 2 Compact. Medan, Fakultas MIPA Universitas Sumatera Utara, 2017; 1-73 (Tesis).

Greenwood D, Irving WL, Barer M, Slack R. th Antimicrobial agents. Medical microbiology. 18 Ed.,

London, Churchill Livingstone, Elsevier, 2012; 54-68. 14. Afifah N, Yuliani R. Aktivitas antibakteri kombinasi Gentamisin dan ekstrak 10 tanaman obat terhadap bakteri Pseudomonas aeruginosa dan Methicillin Resistant Staphylococcus aureus (MRSA). Surakarta, Fakultas Farmasi Universitas Muhammadiyah Surakarta, 2017; 1-10 (Skripsi Thesis).

Long SS, Prober CG, Fischer M. Staphylococcus aureus. Dalam: Daum RS. Principles and practice of

th pediatric infectious diseases. 5 Ed., Philadelphia, Elsevier, 2018; 692-706.

Sulistyaningrum NF, Kuswandi M, Sutrisna EM. Pola kuman dan uji sensitivitasnya terhadap antibiotik pada penderita Infeksi Luka Operasi (ILO) di RSUD Dr.

Moewardi periode Januari-Juli 2015. Surakarta, Fakultas Farmasi Universitas Muhammadiyah

Surakarta, 2015; 1-10 (Naskah Publikasi).

Erikawati D, Santosaningsih D, Santoso S. Tingginya Prevalensi MRSA pada isolat klinik periode 2010-2014 di RSUD Dr. Saiful Anwar Malang, Indonesia. Jurnal Kedokteran Brawijaya, 2016; 29(2): 149-56.

Vinandryano A. Persentase prevalensi dan pola resistensi Methicillin Resistant Staphylococcus aureus pada pasien anak di RSUD Dr. Soetomo Surabaya 2017. Surabaya, Fakultas Kedokteran Universitas Airlangga, 2018; 7-9 (Skripsi Thesis).

Dwiyanti RD, Muhlisisn A, Muntaha A. MRSA dan VRSA pada paramedis RSUD Ratu Zalecha Martapura. Medical Laboratory Technology Journal, 2015; 1(1): 27-33.

Asia Pacific Society of Infection Control. Pedoman APSIC untuk pencegahan infeksi daerah operasi.

Singapura, APSIC, 2018; 1-58.

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Submitted

2020-03-13

Accepted

2020-07-14

Published

2021-04-15

How to Cite

[1]
Chineko, S.I., Pratiwi, D.I.N., Rahmiati, R., Muthmainnah, N. and Yasmina, A. 2021. Antibiotics Susceptibility Pattern of MRSA at Intensive Care Room of Ulin General Hospital Banjarmasin. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 2 (Apr. 2021), 177–183. DOI:https://doi.org/10.24293/ijcpml.v27i2.1649.

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