Relationship between Serum Dehydroepiandrosterone Levels and Heart Ejection Fraction in Heart Failure Patients

Rima Hayyu Chrisnanda, M. Robiul Fuadi, S.P. Edijanto, M. Yusuf


Cardiovascular disease is still a serious problem in the world of health. Life expectancy after being diagnosed with heart
failure is 50% and 10% for 5 and 10 years. Steroid hormones such as Dehydroepiandrosterone (DHEAS) have
cardioprotective effects by inhibiting the formation of atherosclerotic plaque, pulmonary artery vasodilators, and protecting
cardiomyocytes. DHEAS levels decrease with age. Decreased DHEAS levels are associated with an increased risk of
cardiovascular disease. This study aimed to know the relationship between DHEAS levels in serum and ejection fractions in
heart failure patients. This cross-sectional study used a sample of 34 people aged > 30 years who had been diagnosed with
heart failure by a specialist in the Department of Cardiology and Vascular Medicine. The diagnosis of heart failure uses
Echocardiography to determine the ejection heart fraction. DHEAS levels were taken from venous blood and examined
using the CLEIA method with an IMMULITE device (Siemens Healthineers, Germany). Statistical analysis was performed by
Spearman correlation test, with a significance level of p < 0.05. Thirty-four research subjects found that 13 patients had an
ejection fraction of 40% (Heart Failure with Reduced Ejection Fraction/HFrEF), 12 patients had an ejection fraction of 41-49%
(borderline) and 9 patients had an ejection fraction of ≥ 50% (Heart Failure with Preserved Ejection Fraction/HFpEF).
Spearman correlation test results obtained a correlation coefficient or r=0.357 with a value of p=0.038, which meant there
was a significant relationship between DHEAS with ejection fraction (p < 0.05). The lower the DHEAS level, the ejection
fraction would also be lower. Further with age, DHEAS levels get lower. The lower the DHEAS level, the lower the ejection


Dehydroepiandrosterone, DHEAS, ejection fraction, heart failure

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