The Levels of Inhibitory Cytokines in the Serum of Patients with Hepatitis B and C

Authors

  • Ainor Rohmah Sebelas Maret University
  • Sigit Setyawan Department of Parasitology, Faculty of Medicine, Sebelas Maret University, Surakarta
  • Tri Nugraha Susilawati Department of Microbiology, Faculty of Medicine, Sebelas Maret University, Surakarta

DOI:

https://doi.org/10.24293/ijcpml.v27i3.1678

Keywords:

IL-4, IL-10, TGF-β, disease progression, hepatitis B, hepatitis C

Abstract

Hepatitis B and C Viruses (HBV dan HCV) can cause acute or chronic hepatitis that may develop into fibrosis, cirrhosis, and hepatocarcinoma. Previous studies have reported that hepatocyte damage is mainly due to overactive immune responses rather than viral infection. Cytokines are essential mediators in the immune response. This study aimed to determine the correlation between the levels of serum inhibitory cytokines, i.e., IL-4, IL-10, and TGF-β, and the development of liver disease in patients with hepatitis B and C. The levels of serum IL-4, IL-10, and TGF-β from 58 patients with hepatitis B or hepatitis C were determined by ELISA. The progression of liver disease is inferred from the levels of serum transaminases and the degree of liver fibrosis. Data were analyzed using the Spearman correlation test with a p-value of < 0.05 is considered statistically significant. This study showed no correlation between the levels of serum IL-4, IL-10, and TGF-β and the development of liver disease in patients with hepatitis B and C (p > 0.05). Therefore, cytokine testing using ELISA was unable to replace liver biopsy to assess liver disease progression in patients with hepatitis B and C.

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Author Biographies

Ainor Rohmah, Sebelas Maret University

Undergraduate Program in Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta

Sigit Setyawan, Department of Parasitology, Faculty of Medicine, Sebelas Maret University, Surakarta

Department of Parasitology, Faculty of Medicine, Sebelas Maret University, Surakarta

Tri Nugraha Susilawati, Department of Microbiology, Faculty of Medicine, Sebelas Maret University, Surakarta

Department of Microbiology, Faculty of Medicine, Sebelas Maret University, Surakarta

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Submitted

2020-09-08

Accepted

2020-12-08

Published

2021-09-21

How to Cite

[1]
Rohmah, A., Setyawan, S. and Susilawati, T.N. 2021. The Levels of Inhibitory Cytokines in the Serum of Patients with Hepatitis B and C. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 3 (Sep. 2021), 232–237. DOI:https://doi.org/10.24293/ijcpml.v27i3.1678.

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