Comparison between Neutrophil Lymphocyte Ratio and Derived Neutrophil Lymphocyte Ratio as the Risk Factor of COVID-19

Authors

  • Dwi Aryani Department of Clinical Pathology, Sleman General Hospital, Yogyakarta
  • Dea Noviana Pramatik Laboratory of Ghrasia Mental Hospital, Yogyakarta

DOI:

https://doi.org/10.24293/ijcpml.v27i3.1706

Keywords:

COVID-19, risk factor, NLR, d-NLR

Abstract

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Respiratory disorders were the most common sign and symptom of COVID-19. Inflammation on SARS-CoV-2 infection is presumed to play a role in the pathogenesis of COVID-19. The Neutrophil Lymphocyte Ratio (NLR) is one of many biomarkers that has been widely used to assess the risk factors of COVID-19. The derived Neutrophil Lymphocyte Ratio (d-NLR) is a simple, inexpensive, and widely available inflammation biomarker. However, its usage for COVID-19 remains to be further studied. This study aimed to determine the NLR and d-NLR ratio as a risk factor of COVID-19. This study was a retrospective study with a study population of 84 subjects, consisting of 33 patients with positive COVID-19 and 51 patients with negative COVID-19. The result showed that the odds ratio of NLR to COVID-19 was 2.665 with the p-value of 0.047 and confidence interval of 95% 0.998-7.038 at cut-off ≥ 3.1. The odd ratio of d-NLR to COVID-19 was 2.808 with the p-value of 0.026 and confidence interval of 95% 1.129-7.038 at cut-off ≥ 2.0. In conclusion, despite a higher odd ratio of d-NLR compared to NLR, both NLR and d-NLR can be used as a biomarker for the risk factor of COVID-19.

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Author Biographies

Dwi Aryani, Department of Clinical Pathology, Sleman General Hospital, Yogyakarta

Department of Clinical Pathology, Sleman General Hospital, Yogyakarta

Dea Noviana Pramatik, Laboratory of Ghrasia Mental Hospital, Yogyakarta

Laboratory of Ghrasia Mental Hospital, Yogyakarta

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Submitted

2020-10-09

Accepted

2021-05-04

Published

2021-09-21

How to Cite

[1]
Aryani, D. and Pramatik, D.N. 2021. Comparison between Neutrophil Lymphocyte Ratio and Derived Neutrophil Lymphocyte Ratio as the Risk Factor of COVID-19. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 27, 3 (Sep. 2021), 260–264. DOI:https://doi.org/10.24293/ijcpml.v27i3.1706.

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