Prognostic Value of Platelet-Lymphocyte Ratio and High-Density Lipoprotein in Patients with Acute Myocardial Infarct

Authors

  • Lestari Lestari Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar
  • Sulina Yanti Wibawa Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, Stella Maris Hospital, Makassar
  • Amaliyah Tahir Lopa Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, dr. Tadjuddin Chalid Hospital, Makassar
  • Darmawaty Rauf Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, Faisal Islamic Hospital, Makassar

DOI:

https://doi.org/10.24293/ijcpml.v28i1.1730

Keywords:

High-density lipoprotein, platelet to lymphocyte ratio, NSTEMI, STEMI

Abstract

Acute Myocardial Infarct (AMI) is the main reason for mortality. Platelet to Lymphocyte Ratio (PLR) describes thrombocyte aggregation and inflammation that is linked to cardiovascular disease. High-Density Lipoprotein (HDL) is antiatherogenic. This study aims to analyze the prognostic value of PLR and HDL in patients with AMI. This study was a retrospective observational study by obtaining laboratory results from complete blood count and lipid profiles from inpatients with AMI (STEMI and NSTEMI) medical records during Mei 2019–August 2020. Receiver Operating Characteristics (ROC) analysis was done to get the PLR and HDL cut-off. Prognostic value evaluation was based on sensitivity, specificity, positive and negative predictive value, and accuracy. Results obtained were from 302 subjects with a mean age of 58.4+9.6 years old, with most male patients (74.5%). Receiver operating characteristics curve analysis showed an 0.514 Area Under Curve (AUC) for PLR with p=0.685. High-density lipoprotein ROC was 0.573 with a p=0.033 (p< 0.05), with HDL cut-off = 50.0; sensitivity 72.7%, specificity 32.3%, positive predictive value 63.3%, negative predictive value 42.0% and 57.3% accuracy.
Platelet to lymphocyte ratio mean was lower in the HDL <50 group (187.9) compared to the HDL > 50 (210.8), (p=0.009). High-density lipoprotein can be concluded as a potential prognostic factor of acute myocardial infarct. The lower the HDL, the greater the risk for a poor prognosis. A big-scale prospective study should be held to clarify and confirm these findings.

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Author Biographies

Lestari Lestari, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar

Sulina Yanti Wibawa, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, Stella Maris Hospital, Makassar

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, Stella Maris Hospital, Makassar

Amaliyah Tahir Lopa, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, dr. Tadjuddin Chalid Hospital, Makassar

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, dr. Tadjuddin Chalid Hospital, Makassar

Darmawaty Rauf, Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, Faisal Islamic Hospital, Makassar

Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr. Wahidin Sudirohusodo, Makassar/Pathology Clinic Installation, Faisal Islamic Hospital, Makassar

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Submitted

2020-11-11

Accepted

2021-03-01

Published

2021-12-15

How to Cite

[1]
Lestari, L., Wibawa, S.Y., Lopa, A.T. and Rauf, D. 2021. Prognostic Value of Platelet-Lymphocyte Ratio and High-Density Lipoprotein in Patients with Acute Myocardial Infarct. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 28, 1 (Dec. 2021), 46–50. DOI:https://doi.org/10.24293/ijcpml.v28i1.1730.

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