SEL PLASMA LEUKEMIA HUBUNGAN DENGAN MIELOFIBROSIS

Authors

  • Sri Sulistiandari
  • Budiman .

DOI:

https://doi.org/10.24293/ijcpml.v14i3.937

Keywords:

Plasma cell leukemia, myelofibrosis

Abstract

Plasma cell leukemia (PCL) is a variant form of myeloma which contain more than >20% plasma cells and an absolute plasma
cell content ≥ 2.000/mm3 in peripheral blood. PCL is a rare disorder, whole PCL with myelofibrosis is even more rare disorder. The
correlation between plasma cell leukemia and myelofibrosis is unclear. A 59-years-old woman referred to our hospital with general
weakness and severe anemia. Physical examination: looks pale, anaemic of conjunctiva, hepatosplenomegaly. The laboratory findings
are Hb 4.1 gr/dL, MCV 81 fL, MCH 26.7 pg, leucocytes 22.500/mm3, thrombocytes 26.000/mm3, reticulocytes 1.8%. The peripheral
blood showed leucoerythroblastic morphology with teardrop cells and 32% plasma cells. Bone marrow aspiration revealed massive
plasma cell infiltrations (90%). Protein electrophoresis showed hypogammaglobulinemia. There is no evidence of osteolitic bone lesion
on radiological examination. Clinical and laboratory finding above support the diagnosis of Primary Plasma Cell Leukaemia that may
lead to myelofibrosis as a complication. Bone marrow biopsy is required to confirm diagnosis of myelofibrosis.

Downloads

Download data is not yet available.

Downloads

Submitted

2018-03-16

Accepted

2018-03-16

Published

2018-03-16

How to Cite

[1]
Sulistiandari, S. and ., B. 2018. SEL PLASMA LEUKEMIA HUBUNGAN DENGAN MIELOFIBROSIS. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 14, 3 (Mar. 2018), 123–126. DOI:https://doi.org/10.24293/ijcpml.v14i3.937.

Issue

Section

Articles