Lidya Utami, Riadi Wirawan, Alida R Harahap, Abdul Muthalib, Harny Edward


The light chains of immunoglobulin are produced in larger quantity rather than heavy chains, therefore small amount of free light
chains (FLC) can be found in the blood of healthy individuals. Free light chain production is increased in the clone’s proliferation of
malignant B cells, i.e. in myeloma. Therefore the FLC level measurement can be used for diagnosis aid of myeloma and related B cells
disorders. The aim of this study is to establish reference range of serum FLC κ, FLC λ, and κ/λ ratio in population ≥40 year’s old using
immunoturbidimetry assay. Serum FLC κ, FLC λ and κ/λ ratio were measured in 240 healthy male and female attending medical check
up in MMC hospital. Healthy subjects were determined by anamnesis and physical examination, with routine haematology, ESR, and
serum creatinine level within normal ranges. The serum FLC assays were performed in the Clinical Pathology Laboratory, RSCM, using
Hitachi 912 with immunoturbidimetry method. The results were analyzed by SPSS 11.5 program. Serum FLC normal reference value
in 40-84 years old healthy subjects are: FLC κ 11.7–30.6 mg/L, FLC λ 9.7–25.0 mg/L, and κ/λ ratio 0.79–1.75. This research is the
first study for finding serum FLC values in the Indonesian population. The normal reference value found is similar with another study
using the same platform analyzer.


Serum free light chain reference value, immunoturbidimetry

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