PENGUKURAN DAN APLIKASI KLINIK THROMBIN ACTIVATABLE FIBRINOLYSIS INHIBITOR

Mansyur Arif

Abstract


Cross regulation of coagulation and fibrinolysis plays an important role in preserving a balanced hemostatic process. These process
are exquisitely regulated and protect the organism from excessive blood loss or excessive fibrin deposition. Identification of Thrombin
Activatable Fibrinolysis Inhibitor (TAFI) as an inhibitor of fibrinolysis and one of the main intermediates between coagulation and
fibrinolysis, greatly improved our understanding of cross regulation of coagulation and fibrinolysis. As TAFI is an enzyme that is activated
by thrombin generated by the coagulation system, its activation is sensitive to the dynamics of the coagulation system. This review will
discuss the role of TAFI and characterize it with respect to its activation, regulation, and clinical application.


Keywords


TAFI, coagulation, fibrinolysis

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DOI: http://dx.doi.org/10.24293/ijcpml.v16i1.1032

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