GAMMA-GLUTAMYLTRANSFERASE DAN APOLIPOPROTEIN B DENGAN SINDROMA METABOLIK

Abstract

The number of Metabolic Syndrome (MS) patient has been rapidly increased. Diabetes Mellitus (DM) is a risk factor of coronary
heart disease that increased four fold in the general population. Gamma-glutamyltransferase (GGT) is located on the external surface
of most cells and mediates the uptake of glutathione, which is an important component of intracellular antioxidants defenses. The aims
of this study was to analyze the correlation between GGT, Apolipoprotein B and metabolic syndrome parameters, a high sensitivity
C-Reactive Protein (hs-CRP) as a marker of inflammation, and glutathione peroxidase (GPx) as an antioxidant marker in type 2 DM
patients. This study used a cross sectional design. The subject of this study was type 2 DM patients who came to the Endocrinology
Subdivision of Internal Medicine Department and Laboratory of Clinical Pathology at Dr. Moewardi Hospital Surakarta. To analyze this
result, the researchers used Spearman (r) correlation test with significance degree p < 0.05 and confidence interval 95%.The gamma
glutamyltransferase serum showed a weak positive correlation with waist circumference (r = 0.18; p = 0.045) and Apo B with fasting
blood glucose (r = 0.32; p = 0.001); a mild positive correlation between Apo B and triglyceride (r = 0.45; p = 0.001); a weak negative
correlation between HDL cholesterol and GGT (r = –0.22; p = 0.020) and Apo B (r = –0.20; p = 0.027); a weak positive correlation
between hs-CRP and GGT (r = 0.38; p = 0.001), and Apo B (r = 0.18; p = 0.042); and a weak negative correlation between Apo B
and GPx (r = –0.22; p = 0.019). Gamma-glutamyltransferase examination is superior to notice any inflammatory process than apoB
(r = 0.38 vs. R = 0.18), whereas apoB is superior as a predictor of inflammation than GGT (r = –0.51 vs. R = –0,20). Gamma
glutamyltransferase serum as an early marker of oxidative stress and Apo B was related to inflammation at the metabolic syndrome
and diabetes. Measurement of GGT serum is reliable, easy, and not expensive, it might have important implications both clinically and
epidemiologically