PROCALCITONIN DAN INTERLEUKIN-6 PADA SEPSIS DENGAN GEJALA SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS)

Indranila KS, Tjahjati DM, Emma Emma

Abstract


Sepsis is the cause of patient’s death in the intensive care unit. Sepsis is an inflammatory response to infections. Infection when
continued can cause systemic inflammatory response syndrome (SIRS). Clinical signs and pathology of SIRS are similar to sepsis, thus
clinical as well as laboratory examination is needed to distinguish these. Culture result usually can be seen at least 24 hours after
sampling. In this case a test is needed to diagnose sepsis quickly so that the patient does not experience more severe conditions. The
indicator used in the diagnostic procedure is to know the diagnostic value of procalcitonin (PCT) levels as well as of interleukin-6 (IL-6)
for the diagnosis of sepsis. Thirty-two blood samples of patients treated in the Department of SIRS. Dr. Kariadi Semarang were taken
consecutively from November 2011 up to January 2012. PCT levels are determined by ELFA, levels of IL-6 were determined by ELISA
method. To determine the sensitivity, specificity, positive predictive value and negative predictive value, 2 × 2 table was used. The ROC
curve (receiver operating characteristic) showed an area under the curve of PCT of 0.83 (95% CI = 0.66 to 0.99), cut-off 5.1 ng/mL was
used as an indicator of sepsis. PCT diagnostic test results showed 88.9% sensitivity, 73.9% specificity, 57.1% positive predictive value and
negative predictive value of 94.4%. The area under the curve for IL-6 was 0.67 (95% CI = 0.47 to 0.86), cut off 47.2 pg/mL as an indicator
of sepsis. Diagnostic tests results showed 77.8% sensitivity, 60.9% specificity, 43.7% positive predictive value and negative predictive value
of 87.5%. It can be concluded that the examination of serum PCT levels can be used as a diagnostic test (screening test) for sepsis.


Keywords


SIRS, sepsis, PCT levels, the levels of IL-6, culture

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DOI: http://dx.doi.org/10.24293/ijcpml.v19i2.1064

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