METODE BROMCRESOL GREEN (BCG) DAN BROMCRESOL PURPLE (BCP) PADA SIROSIS HATI YANG MENDAPAT INFUS ALBUMIN
DOI:
https://doi.org/10.24293/ijcpml.v20i2.1070Keywords:
Albumin infusion, bromcresol green (BCG), bromcresol purple (BCP), liver cirrhosisAbstract
Albumin infusion is one of the therapeutic options in hypoalbuminemia patients. Serum albumin can be used to determine the albumin
infusion therapy, prognosis and monitoring of liver cirrhosis. The time difference in measurement of serum albumin by bromcresol green
(BCG) and bromcresol purple (BCP) methods can give different results. Serum albumin examination was done in 20 sera taken from
cirrhosis patients. Serum albumin was then evaluated before treatment, one (1) hour and 24 hours after the patient received an infusion
of albumin and examined by bromcresol green (BCG) and bromcresol purple (BCP) methods. The serum albumin level by BCG method
increased with a coefficient of 0.12 (p-value=0.022) with BCG method before (1.94±0.32 mg/dL) and after one (1) hour (2.06±0.32
mg/dL) receiving intravenous albumin. The coefficient of albumin levels before and after 24 hours (2.12±0.38 mg/dL) was 0.18 (pvalue=
0.07), whereas the increased levels of serum albumin after one (1) hour and after 24 hours of intravenous albumin, were not
significant (p-value=0.467). The BCP method showed that serum albumin before, after one (1) hour and after 24 hours receiving
intravenous albumin were 1.68±0.36 mg/dL, 1.87±0.36 mg/dL and 2.12±0.63 mg/dL respectively. The albumin levels showed a
significant increase before and after one (1) hour infusion of albumin (p-value=0.00), both levels shown before and after 24 hours
(p-value=0.001), as well as one (1) hour and 24 hours after receiving intravenous albumin (p-value=0.04). The results of this study
showed that increased serum albumin by BCG method could be detected after 1 (one) hour, whereas by BCP method could only be detected
after 24 hours receiving intravenous albumin.