RUSIP SEHUBUNGAN PROFIL LIPID DALAM KEADAAN HIPERKOLESTEROLEMIA

Abstract

Rusip is a fermented fish product made from anchovies. Several lactic acid bacteria have been identified in rusip fermentation. Lactic
acid bacteria are known to be able to reduce serum cholesterol. The aim of the research was to know the lipid profile changes due to
administration of rusip in hypercholesterolemia rats. The research was done by using Pre and Post Randomized Controlled Group Design.
The research subjects consisted of twenty-eight Sprague Dawley strain white male rats aged 20 weeks with normal body weight, who were
given a high-fat high-cholesterol diet, then divided into four (4) groups: control group, without Rusip administration; P1, P2 and P3 who
received 2.55; 5.10 and 7.65 mg Rusip/g body weight. After 14 days treatment, blood samples were taken to determine the lipid profile
using enzymatic methods. ANOVA or alternative test, was used to test the difference between the groups at the 95% confidence level. Based
on the research, the administration of Rusip in the treatment group caused significant changes in the lipid profiles of hypercholesterolemia
rats (p<0.05). The total cholesterol, triglycerides and LDL cholesterol levels decreased significantly in all three treatment doses (p<0.05).
The HDL cholesterol increased significantly in all three treatment doses (p<0.05). The highest change in lipid profile results was obtained
in the treatment of P3 to all variables. In this study, it was found that administration of Rusip could improve the state of blood lipid
profiles of hypercholesterolemia rats. Whereas, the highest changes were obtained in treatment with P3.