RDW, JUMLAH TROMBOSIT DAN RPR DENGAN INDEKS FIB-4 DI HEPATITIS C

Abstract

Hepatitis C virus infection is one of the main causes of worldwide chronic liver disease. The determining of fibrosis level in the liver
disease is essential. The red blood cell distribution width (RDW) is a potential prognostic index for liver disease. The platelet (PLT)
count has been used as the biomarker for liver fibrosis. RDW to platelet ratio (RPR) is devised to amplify the difference in the RDW and
platelets among patients with different liver fibrosis stages. Fibrosis 4 (FIB-4) indexes are accurate non-invasive methods to predict the
level of liver fibrosis of HCV-monoinfected patients. The objective of this study is to know the correlation of RDW, PLT count, and RPR with
FIB-4 index in hepatitis C patients by analyzing them. The study was carried out observationally with cross sectional approach between
February−March 2015 at the Dr. Kariadi Hospital, on samples collected consecutively from the medical records of hepatitis C patients.
The data processing was performed with Pearson/Spearman correlation. There was a strong positive correlation between RDW and FIB-4
index (r=0.624; p=0.000) and between RPR with FIB-4 index (r=0.674; p=0.000), while there was a strong negative correlation
between PLT count and FIB-4 index (r=-0.600; p=0.000). From this study it can be concluded that there was an increased RDW and RPR
resulting in a higher FIB-4 index. There was also found a decreased PLT resulting from higher FIB-4 index .The opinion of the researchers
is that further studies for prospective multicentres are needed to be carried out, so that the results can be more generalized.