PLATELET AGGREGATION IN ACUTE CORONARY SYNDROME

Abstract

Haemostatic system is the mechanism that controls response of bleeding or thrombosis, so that thrombogenesis and fibrinolysis are in
balance. Obstruction of brain and heart vascular system often occurred, because of the hyperactivity of thromboses function that causes
thrombosis. CBC, blood glucose, lipid profile and cardiac enzyme assay were performed on acute coronary syndrome patients at the
Emergency Department as well as at the normal control. In this study, each group consist of 10 patients. Platelet aggregation test was
measured with turbidimetric method using Helena Agram aggregometer. ADP and epinephrine 5 and 10 µM were used as the agonists.
There was significant difference in the mean total cholesterol, LDL and blood sugar level in the acute coronary syndrome patients than
the control group. Platelet aggregations with ADP 1 and 5 µM were significantly different in the acute coronary syndrome patients than
the control one. In this study were found patients aged above 50 years old have platelet aggregation with ADP 10 µM, which differ
significantly than the control group.