UMBI UBI JALAR UNGU BALI (Ipomoea batatas) DI TRANSAMINASE SERUM, MALONDIALDEHIDE HEPAR DAN ALKOHOL KRONIS

I Wayan Putu Sutirta-Yasa, I Made Jawi, Ida Bagus Ngurah, Anak Agung Ngurah Subawa

Abstract


Oxidative stress as a consequence of chronic alcoholic intake causes lesions of liver tissue. The objective of this study was to identify
the antioxidant effect of ethanol extract derived from Balinese purple sweet potato on the liver tissue in mice after chronic consumption
of alcohol. Subjects of this study were 32 adults male Swiss mice (12–14 weeks) divided into 4 groups with control group post-test
only design. Post-treatment of blood and liver samples were collected from each group of 8 mice. The MDA liver was quantified with
thiobarbituric acid reactive substances (TBARS) method. Samples were collected from control group of 8 mice without sweet potato
extract and alcohol, 8 mice with 1 mg extract of Balinese purple sweet potato, 8 mice with 0.8 gram alcohol, and 8 mice with combine
of alcohol and extract of Balinese purple sweet potato, each treatment was carried out every day for 4 weeks. The results showed a
significant increase of serum SGOT, SGPT and liver MDA level, after chronic consumption of alcohol (p = 0.00). The decrease of serum
SGOT, SGPT and liver level MDA was significant in the group with extract of Balinese purple sweet potato (p = 0.00). The researchers
concluded that the extract of Balinese purple sweet potato had an antioxidant effect in mice which consumed alcohol chronically. Based
on this study it is concluded that extract of Balinese purple sweet potato has a protective effect on the liver cell in mice which consumed
alcohol chronically.


Keywords


Chronic alcohol consumption, Balinese purple sweet potato, SGOT, SGPT, liver MDA

Full Text:

PDF


DOI: http://dx.doi.org/10.24293/ijcpml.v17i3.1170

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.