LEVELS OF INTERLEUKIN-6 AND TUMOR NECROSIS FACTOR ALPHA IN PREGNANT PATIENTS WITH PREECLAMPSIA AND PATIENTS WITH NORMAL PREGNANCY

Mawardi Sarengat, Ratna Akbari Ganie, Sarma N. Lumbanraja

Abstract


Preeclampsia is a pathological condition often found during pregnancy with a prevalence of about 5-7%. Abnormal implantation, abnormal trophoblast invasion, and endothelial cell dysfunction will result in increased proinflammatory cytokines. One of preeclampsia’s pathogenesis is increasing levels of TNF-alpha and IL-6. Because of this, the researchers wanted to know the level of expression of TNF-alpha and Interleukin-6 in pregnant females with preeclampsia. This was an analytical study with a case-control design, done on 30 preeclampsia patients at the Adam Malik Hospital Medan in August - October 2016, who fulfilled the inclusion criteria of the study. IL-6 and TNF-alpha level were then examined, engage ethnic by ELISA with Human Interleukin-6 QY-E04262 reagent and Human Tumor Necrosis Factor-Alfa QY-E00182 reagent. The results of IL-6 in patients with preeclampsia increased (48.60±10.85) as compared to the control (31.99±2.65). TNF-alpha levels in patients with preeclampsia also increased (79.24±10.43) compared to the control (79.24±10.43). Statistical results showed significant differences in the expression of TNF-alpha and IL-6 levels in patients with preeclampsia compared with controls (p=0.0001). In this research, there were significant differences in the expression of TNF-alpha and IL-6 levels in preeclampsia patients.


Keywords


Preeclampsia, TNF alfa, IL-6

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References


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DOI: http://dx.doi.org/10.24293/ijcpml.v25i2.1171

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