Mawardi Sarengat, Ratna Akbari Ganie, Sarma N. Lumbanraja


Preeclampsia is a pathological condition often found during pregnancy with a prevalence of about 5-7%. Abnormal implantation, abnormal trophoblast invasion, and endothelial cell dysfunction will result in increased proinflammatory cytokines. One of preeclampsia’s pathogenesis is increasing levels of TNF-alpha and IL-6. Because of this, the researchers wanted to know the level of expression of TNF-alpha and Interleukin-6 in pregnant females with preeclampsia. This was an analytical study with a case-control design, done on 30 preeclampsia patients at the Adam Malik Hospital Medan in August - October 2016, who fulfilled the inclusion criteria of the study. IL-6 and TNF-alpha level were then examined, engage ethnic by ELISA with Human Interleukin-6 QY-E04262 reagent and Human Tumor Necrosis Factor-Alfa QY-E00182 reagent. The results of IL-6 in patients with preeclampsia increased (48.60±10.85) as compared to the control (31.99±2.65). TNF-alpha levels in patients with preeclampsia also increased (79.24±10.43) compared to the control (79.24±10.43). Statistical results showed significant differences in the expression of TNF-alpha and IL-6 levels in patients with preeclampsia compared with controls (p=0.0001). In this research, there were significant differences in the expression of TNF-alpha and IL-6 levels in preeclampsia patients.


Preeclampsia, TNF alfa, IL-6

Full Text:



Cnossen, JS, van der Post, J, Mol, B, Khan, KS, Meads, CA, ter Riet, G. Study Protocol Prediction of Pre-eclampsia: A Protocol for Systematic Reviews of Test Accuracy. BMC Pregnancy and Childbirth 2006, 6: 29.

Gupta M, Chari S, Chandankhede M, Ghike S. Levels of Tumor Necrossi Factor- Alpha in Pre-Eclampsia.

Decherney, AH, Nathan, L, Goodwin, TM, Laufer, N (eds.). Chapter19 Hypertension in Pregnancy. In: Current Diagnosis & Treatment Obstetrics & Gynecology Tenth Edition. United States of America: The McGraw-Hill Companies; 2007.

Cunningham, FG, Leveno, KJ, Bloom, SL, Hauth, JC, Rouse, DJ, Spong, CY. Chapter 34 Pregnancy Hypertension. In: Williams Obstetric 23rd Edition. United States: The McGraw-Hill Companies; 2010. p706-14.

Pedoman Pengelolaan Hipertensi dalam Kehamilan di Indonesia Edisi 2. Batam: Pokja Penyusunan Pedoman Pengelolaan Hipertensi dalam Kehamilan di Indonesia Himpunan Kedokteran Feto Maternal; 2005.

Roudsari FV, Ayati S, Ayatollahi H, Esmaeily H, Hasanzadeh M, Shahabian M, et al.

Comparison of Maternal Serum Tumor Necrosis Factor (TNF-α) in Severe and Mild Preeclampsia versus Normal Pregnancy. Iranian Journal of Reproductive Medicine 2009; 7 (4): 153-6.

Hung Wei, L. et al. The Anti-Apoptotic Role of Interleukin-6 in Human Cervical Cancer is Mediated by Up-Regulation of Mcl-1 through A PI 3K/Akt Pathway. Oncogene 2001; 20: 5799-809.

Kalai, M., et al. Analysis of the Mechanism of Action of Anti-human Interleukin-6 and Anti-Human Interleukin-6 Receptor-Neutralising Monoclonal Antibodies. Eur J.

Biochem 1997;249, 690-700.

Afshari JT, Ghomian N, Shameli A, Shakeri MT, Fahmidehkar MA, Mahajer E, et al. Determination of Interleukin-6 and Tumor Necrosis Factor- Alpha Concentrations in

Iranian- Khorasanian Patients with Preeclampsia. BMC Pregnancy and Childbirth 2005; 5:14. doi: 10.1186/1471-2393-5-14.

Casart YC, Tarrazzi K, Camejo MI. Serum Levels of Interleukin-6, Interleukin-1β and Human Chorionic Gonadotropin in Pre-eclamptic and Normal Pregnancy.

Gynecological Endocrinology, May 2007; 23 (5): 300-3.

Dabagh- Gorjani FAnvari F, Zolghadri J, Kamali-Sarvestani E, Gharesi- Fard B. Differences in the Expression of TLRs and Inflammatory Cytokines in Pre- Eclamptic Compared with Healthy Pregnant Women. Iran J Immunol 2014; 11(4): 233-245.

Raghupathy R. Cytokines as Key Players in the Pathophysiology of Preeclampsia. Med Princ Pract 2013; 22 (suppl 1): 8- 19. doi: 10.1159/000354200.

Tayal D, Goswami B, Patra SK, Tripathi R, Khaneja A. Association of Inflammatory Cytokines, Lipid Peroxidation End Products and Nitric Oxide with Clinical Severity and Fetal Outcome in Preeclampsia in Indian Women. Ind J Clin Biochem (Apr- June 2014); 29 (2): 139-44.

DOI: http://dx.doi.org/10.24293/ijcpml.v25i2.1171


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.