MIELOMA MULTIPEL NONSECRETORY (Nonsecretory Multiple Myeloma)

Abstract

The incidence of non-secretory multiple myeloma ranged between 1−5% cases of plasma cell dyscrasia (PCD). In the developed
countries like in Europe, cases of MM ranged from 4.5 up to 6.0/100.000 population/year with a median age at diagnosis between
63 and 70 years. A very rare disease with difficulties in diagnosis in the clinical practice is the main reason for reporting this case.
A nonsecretory MM (MMNS) case was reported in a 36–year-old male with multiple osteolytic lesions and bone pain; whereas renal
insufficiency as well as anemia was not found. The protein electrophoresis result showed a presence of hypoglobulinemia. On bone marrow
aspiration (BMA) there was an infiltration of about 40% of plasma cells. Nonsecretory was due to a disruption of immunoglobulin
secretion, so M protein was not found in immuno-fixation electrophoresis. Epidemiological data showed that the incidence of MM in
young age is very low. The diagnosis of MMNS is established when a plasmocyte neoplasm is not accompanied by renal insufficiency,
hypercalcemia and decreased levels of normal immunoglobulin.