DIFFERENTIAL CELL COUNT AS DIAGNOSTIC AND PROGNOSTIC MARKER OF ACUTE MYOCARDIAL INFARCTION

Authors

  • Sri Anita Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia
  • Liong Boy Kurniawan Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia
  • Darwati Muhadi Department of Clinical Pathology, Faculty of Medicine, Hasanuddin University/Dr Wahidin Sudirohusodo Hospital, Makassar, Indonesia

DOI:

https://doi.org/10.24293/ijcpml.v24i2.1320

Keywords:

Leukocyte, differential cell count, acute myocardial infarction, mortality

Abstract

Myocardial infarction is a necrosis of myocardial cells due to lack of blood and oxygen supply caused by obstruction of coronary arteries, mostly due to atherosclerosis processes. Increased inflammatory marker level is associated with poor cardiovascular prognosis. This study was aimed to know whether leukocytes count, differential cell count and the Ratio of Neutrophils-Lymphocytes (RNL) could distinguish between types of Acute Myocardial Infarction (AMI) and to evaluate its correlation with mortality. This was a cross-sectional retrospective study using medical records patients which were diagnosed as AMI by clinicians in Cardiac Centre of the Dr. Wahidin Sudirohusodo Hospital during the period of April 1st, 2015 - May 31st, 2016. Statistical analysis used the Mann-Whitney and Chi-Square test, p<0.05 was considered as significant. The total subjects were 435 patients divided into 289 ST- Elevation Myocardial Infarction (STEMI) and 146 Non-ST-Elevation Myocardial Infarction (NSTEMI). There were significant differences in that mean of leukocytes, neutrophils, lymphocytes, monocytes, eosinophils counts and RNL between STEMI and NSTEMI (p <0.05). Significant differences were also found in leukocyte, neutrophils, lymphocytes, eosinophils, basophils and RNL mean between those who died and survived (p <0.05) and a significant correlation between increased leukocytes, neutrophils, basophils counts with mortality (p <0.05). In conclusion, the number of leukocytes and leukocyte count can be used as diagnostic markers of AMI between STEMI and NSTEMI, as well as prognostic markers among patients who died and survived. Routine blood sampling cohort studies in patients with AMI can avoid the bias of the results obtained.

 

Downloads

Download data is not yet available.

References

World Health Organization. Prevention of Recurrences of Myocardial Infarction and Stroke Study, the PREMISE Programme: Country Projects. 2016; 820-31.

World Health Organization in Collaboration with the World Heart Federation, and the World Stroke Organization. Global Atlas on Cardiovascular Disease Prevention, and Control. 2011; 8-13.

The Ministry of Health of the Republic of Indonesia. Heart Health Situation. Information Center, and the Ministry of Health. 2014; 1-8.

Aspar A, Budiono B. The Procedure Remains the Cardiovascular Care Unit Medical Services Dr. Wahidin Sudirohusodo Hospital. Raw Ministry Cardiovascular Disease. 2006; 59-69.

Alwi, I. Acute Miokard Infarction with ST elevation. In: Textbook of Medicine. 6th Ed., University of Indonesia, Jakarta, Agency Publisher Faculty of Medicine, 2014; 1457-1474.

Myrta R. Pathophysiology of Acute Coronary Syndrome. World Mirror of Medicine. 2012; 39 (4): 261-4.

Kurniawan L.B, Bahrun U, Darmawaty, Arif M. Effect of Total Leukocytes Against Mortality in Acute Myocardial Infarction Patients During Treatment. Mirror World Medical, 2015; 42(10): 727-30.

Maison D. Role of Leukocytosis as Diagnostic Test added in Acute Myocardial Infarction. Semarang, Diponegoro University. 2000; 1-40.

Abbase AL, Khadim MAK. Leukocytes Count and Neutrophil/Lymphocytes Ratio in Predicting in-Hospital Outcome after Acute Myocardial Infarction. Medical Journal of Babylon. 2010; 7(4): 480-9. Doi: 1812-156X-7-4.

Gazi E, Bayram B, Gazi S, Temiz A, Kirilmaz B, Altun B, et al. Prognostic Value of the Neutrophil-Lymphocyte Ratio in Patients with ST-Elevated Acute Myocardial Infarction. Clin Appl Thromb Hemost. 2015; 21(2): 155-9.

Downloads

Submitted

2018-09-30

Accepted

2018-09-30

Published

2018-09-30

How to Cite

[1]
Anita, S., Kurniawan, L.B. and Muhadi, D. 2018. DIFFERENTIAL CELL COUNT AS DIAGNOSTIC AND PROGNOSTIC MARKER OF ACUTE MYOCARDIAL INFARCTION. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 24, 2 (Sep. 2018), 175–179. DOI:https://doi.org/10.24293/ijcpml.v24i2.1320.

Issue

Section

Articles