Correlation between Alpha Fetoprotein and Platelet Profile in Hepatocellular Carcinoma
DOI:
https://doi.org/10.24293/ijcpml.v26i1.1353Keywords:
HCC, AFP, platelet profile, cirrhosisAbstract
Hematology abnormalities are commonly found in Hepatocellular Carcinoma (HCC) patients. Platelet (PLT) count in HCC can be low, normal or high, and influenced by tumor and liver damage. There are limited studies about the correlationp between AFP and platelet profile of HCC in Indonesia, especially in Makassar. This study is aimed to analyze the correlation between AFP and platelet profile in HCC patients. A retrospective cross-sectional study was carried out from January 2016 to June 2017 on 231 HCC subjects. The correlation between AFP and platelet profile, the correlation of AFP and platelet profile with the diagnosis were analyzed by Independent t-test and Chi-Square. There was no significant correlation between AFP and PLT profile and no significant correlation between AFP and HCC with and without cirrhosis with p>0.05 and p=0.094, respectively. Platelet count and PCT were significantly lower in cirrhotic HCC ompared to non-cirrhotic HCC (p<0.01, p<0.01, respectively), PDW and MPV were significantly higher in cirrhotic HCC compared to non-cirrhotic HCC (p<0.05, p<0.05, respectively). Mean platelet count and PCT in cirrhotic HCC were significantly lower compared to non- cirrhotic HCC, and mean PDW and MPV in cirrhotic HCC c were significantly higher compared to non-cirrhotic HCC. Further research was suggested to evaluate tumor size and nodules of HCC.
Downloads
References
Unggul B. Karsinoma Hati dalam Buku Ajar Imu Penyakit Dalam Edisi VI Jilid III. Jakarta: Interna Publishing.2015;3040-6.
Prakash G. Hepatocellular Carcinoma In The Washington Manual® Subspecialty Consult Series on Gastroenterology Third Edition. Baltimore: Lippincott Williams and Wilkins.2012;221-53.
Bruix J., Sherman M. Management Of Hepatocellular Carcinoma: An Update. Hepatol 2011; 53:1020–1022.
Rino A., Irsan H., Ali D., dkk. Konsensus Nasional Penatalaksanaan Hepatitis B di Indonesia. Jakarta: Perhimpunan Peneliti Hati Indonesia. 2012:1-3.
Gangireddy K., Sridhar S., Talla S., et al. Management Of Thrombocytopenia In Advanced Liver Disease. Can J Gastroenterol Hepatol. 2014;28(10):558-564.
Pons F., Varela M., Llovet JM. Staging Systems In Hepatocellular Carcinoma. HPB : The Official Journal of the International Hepato Pancreato Biliary Association. 2005;7(1):35-41.
Hiromitsu H., Toru B., Ken S., et al. Management Of Thrombocytopenia Due To Liver Cirrhosis. World J Gastroenterol. 2014; 20(10): 2595-2605.
Brian C., Vito G. Thrombocytosis And Hepatocellular Carcinoma. Dig dis sci 2013; 58(6): 1790-1796.
Qing P., Kai Q., Jing Y., et al. The Prognostic Value of Platelet Count in Patients With Hepatocellular Carcinoma. Medicine. 2015; 94(37):1-8.
Yilmas Y., Erdat E., Atabey N., et al. Platelet, Microenvirontmet And Hepatocellular Carcinoma. Biochem Anal Biochem 2016;5:281.
Carr B., Guerra V. Hepatocelluler Carcinoma Size: Platelets, Gamma Glutamyl Transpeptidase, And Alkaline Phosphatase. Oncology 2013;85:153-159.
Kurt M., Onal I., Sayillir A., et al. The Role Of Mean Platelet Volume In The Diagnosis Of Hepatocellular Carcinoma In Patients With Chronic Liver Disease. Hepato-Gastrolenterology 2012;59:00-00.
Venook A., Christos P., Junji F., et al. The Incidence and Epidemiology Of Hepatocellular Carcinoma: A Global and Regional Perspective. The Oncologist 2010;15:5–13.
Serag W. Alpha Fetoprotein and Platelets as Useful Markers for Child Pugh Classification in Male Egyptian Patients With Hepatitis C Virus. IOSR-JDMS 2015;14:26-9.
Rino A., Maulana S., Irsan H., dkk. Performance of Alpha Fetoprotein In Combination With Alpha-1-acid Glycoprotein For Diagnosis Of Hepatocellular Carcinoma Among Liver Cirrhosis Patients. Acta Medica Indonesiana 2015;47:216-22.
Arrieta O., Bernardo C., Daniela M., et al. The Progressive Elevation Of Alpha Fetoprotein For The Diagnosis Of Hepatocellular Carcinoma In Patients With Liver Cirrhosis. BMC Cancer 2007;7:28.
Kurt M., Ibrahim K., Abdurrahim S., et al. The Role of Mean Platelet Volume in the Diagnosis of Hepatocellular Carcinoma in Patients with Chronic Liver Disease. Hepato-Gastroenterology 2012; 59:34-7.
Yasemin U., Murat P., Kagan H. The Use Of Platelet Indices, Plateletcrit, Mean Platelet Volume And Platelet Distribution Width In Emergency Non-Traumatic Abdominal Surgery. Biochemia Medica 2016;26:178–93.
Downloads
Submitted
Accepted
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
