Arfandhy Sanda, Uleng Bahrun, Ruland DN. Pakasi, Andi Makbul Aman


Diabetes Mellitus is a metabolic disease which is still a public health problem till now. World Health Organization (WHO) and International Diabetes Federation (IDF) predict an increase in the number of diabetics which become one of the global threats. Some evidences showed that vitamin D deficiency might influenced in pathogenesis of Type 2 Diabetes Mellitus that caused by insulin resistence and dysfunction of pancreatic beta cell. The objectives of this study is To analyze Vitamin D levels in Type 2 Diabetes Patients that consist of prediabetic group, controlled Type 2 Diabetes Mellitus Group, and uncontrolled Type 2 Diabetes Mellitus. The method used is a cross sectional study. During the study period, a total of 93 samples were obtained which met the study criteria. The sample consist of 33 prediabetic subjects, 30 controlled Type 2 DM subejcts, and 30 uncontrolled Type 2 DM. The study sample consist of 49(52,7%) men and 44(47,3%) women with minimum age 20 years and maximum 79 years (mean 56,59+12,15 years). The minimum HbA1c level was 4,8% and the maximum level was 12,9% (mean 6,95+1,81%). The minimum Vitamin D level was 9,07 ng/ml danĀ  the maximum level was 66,49 ng/ml (mean 26,85+9,30 ng/ml). Kruskal Wallis test showed p value=0,132, Spearman correlation test showed p value>0,05. The clonclusion from this study, there is no significant correlation between vitamin D level and type 2 Diabetes Melllitus consist of Prediabetic group, controlled Type 2 Diabetes Mellitus, and uncontrolled type 2 Diabetes Mellitus.


Type 2 diabetes mellitus, vitamin D, HbA1c

Full Text:



Afzal S, Bojesen SE, Nordestgaard BG. 2013. Low 25(OH)D and Risk of Type 2 Diabetes Mellitus: A Prospective Cohort Study and Meta-analysis, 59:2

American Diabetes Association. 2013. Standard of Medical Care in Diabetes, Diabetes Care, vol.36 (Suppl 1): s11-s50.

Carvalho EF, Griz LHM, Bandeira F, Vitamin D and diabetes mellitus: an update-2013. Arq Bras Endocrinology Metabolic. 2014;58/1.

Chiu CK, Chu A, Saad FM. 2004. Hypovitaminosis D is associated with insulin resistance and cell dysfunction, Am J CliN Nutr, 79:820-5.

Corwin EJ. 2008. The pancreas and diabetes mellitus in Handbook of Pathophysiology, 3rd edition, Philadelphia, Lippincott Williams and Wilkins. 550-573.

Tsur A, Feldman BS. 2013. Decreased serum concentrations of 25-hydroxycalciferol are associated with increased risk of progression to impaired fasting glucose and diabetes. Diabetes Care. Valume 36.

Deleskog A, Hilding A, Birismar K, 2012. Low serum 25(OH)D predicts progression to type 2 diabetes in individuals with prediabtes but not with normal glucose tolerance, 55: 1668-78

Eliades M, Pittas AG. 2009. Vitamin D and Type 2 Diabetes, Clinic Rev Bone Miner Metabolic.

Epstein S. 2010. Vitamin D in Endocrinology and Metabolism Clinics in North America, volume 39, Number 2; 243-446

Pittas AG, Joseph L, Hughes DB. 2007. Review: The Role of vitamin D and calcium in type 2 diabetes. A Systematic Review and Meta-Analysis. JCEM.p: 2017-29.

Griz LHM, Bandeira F, Andrade M, Gabbay L, Dib SA, de Carvalho EF. Vitamin D and Diabetes Mellitus: an update-2013. Arq Bras Endocrinol Metab. 2014;58/1.

Harinarayan CV. 2014. Vitamin D and Diabetes Mellitus. Hormones, 13(2):163-81.

Hesmat R, Malazy OT. 2012. Effect of Vitamin D on Insulin Resistance and arthropometric parameters in type 2 diabetes; a randomized double blind clinical trial, Journal of Pharmaceutical Sciences.

Silambanan S, Jothimalar, Laksmi G. Vitamin D Status in Type 2 Diabetes Mellitus. International Journal of Clinical Biochemistry and Research. 2015; 2(3):140-142.

Lui J. 2013. Vitamin D and Diabetes Melitus: What Do We Know? Journal of Hypo and Hyperglycemia.

Masharani U. 2007. Diabetes Melitus & Hypoglycemia in Current Medical Diagnosis & Treatment. 46th Edition. Mc-Graw Hill Medical, Toronto. 1219-21.

Mathieu C, Gysemans C, Guiletti A. 2005. Vitamin D and diabetes. Diabetologia; 48:1247-57.



  • There are currently no refbacks.