Rika Andriany, Ibrahim Abdul Samad, Mansyur Arif


A liver biopsy is the gold standard for diagnosing and staging liver fibrosis in chronic hepatitis B patient but with many disadvantages so it is difficult to use as a routine examination. Research on index based on serum marker is helpful in predicting liver fibrosis. We conducted a study of the alpha-fetoprotein (AFP) and partial activated thromboplastin time (APTT) index or AA index in relation to the degree of liver fibrosis in chronic hepatitis B patients. This study was a retrospective cross-sectional study in dr.Wahidin Sudirohusodo Hospital Makassar by taking the data from medical records of chronic hepatitis B patients from January 2015 to December 2016. Samples were chronic hepatitis B patients who were tested for AFP, APTT and Fibroscan. The result showed the total of 79 chronic hepatitis B patients, 23 with severe fibrosis, 9 with moderate fibrosis, 26 with mild fibrosis, and 21 with no fibrosis. Spearman correlation test showed a significant correlation between the AA index and the degree of fibrosis (p <0.001) and showed a positive correlation between both of them with a very strong correlation (r = 0.830). Oneway Anova test showed a significant difference between the AA index and the  degree of fibrosis (p<0.001). The results of this study indicate that the AA index can be used as a predictor of fibrosis in chronic hepatitis B patients. It is suggested to do another study with larger sample based on the degree of fibrosis.


AFP, APTT, AA index, degree of fibrosis, chronic hepatitis B

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Sulaiman AS, Pendekatan Terkini Hepatitis B dan C dalam Praktik Klinis Sehari-hari, Jakarta, Sagung Seto, 2010 ; p.1-16.

Dienstag JL. Chronic Hepatitis in Harrison's Gastroenterology and Hepatology. New York: The McGraw-Hill Companies; 2010; p 390-414.

Soemohardjo S, Gunawan S. Hepatitis B Kronik dalam Ilmu Penyakit Dalam, Edisi ke-6, Jilid II, Jakarta, Interna publishing, 2014: 1963-1971.

Lewis G. Coagulation disorder as a presentation of Liver fibrosis in International Journal of Clinical and Experimental Medicine. 2014: 1-6

PPHI, Sirosis Hati, [cited at April 5, 2017]. Available at

WHO. Background in Guidelines for The Prevention, Care and Treatment of Persons With Chronic Hepatitis B Infection. Switzerland: World Health Organization; 2015: 14-24.

Kochar R, Arguedas MR, Fallon MB. Chirrosis of The Liver and Its Complication in Cecil Essentials of Medicine 8th Edition. Philadelphia: Saunders Elsevier. 2010: 478-87.

Feng L et al. A Novel Non-invasive Index using AFP APTT is associated with liver fibrosis in patient with chronic hepatitis B Infection : A Retrospective Cohort Study in British Medical Journal. 2015: 1-7.

Liu Yu et al. Alpha Fetoprotein as a biomarker of Liver Fibrosis Patient : A cross sectional study in PMC Articles. 2014 ; 1-9.

Siddiqui et al. Coagulation Abnormalities in Patients with Chronic Liver disease. Pakistan in Park med Journal. 2011 ; 1-7.



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