Andini Triasti Siregar, Nizam Zikri Akbar, Burhanuddin Nasution


Diabetes has been associated with Coronary Artery Disease (CAD). The atherosclerosis, underlying the pathogenesis of CAD, has been activated since the early stages of hyperglycemia and accelerated with uncontrolled blood sugar level fluctuations. Therefore, sensitive glycemic markers are required to be used as a screening instrument such as a traditional glycated hemoglobin A1c (HbA1c) glycated hemoglobin marker and non-traditional Glycated Albumin (GA). This study was a cross-sectional conducted on May - July 2017 at the Adam Malik Hospital Medan. Subjects were patients with HbA1c> 7%, Hb> 10 g/dL and albumin> 3 g/dL, divided into DM+CAD and non-CAD DM groups. Sixty patients participated in this study consisting of 36 males (60%) and 24 females (40%), with a mean age of 56 years. There was a significant difference between HbA1c and GA between the non-CAD DM group and DM + CAD (p=0.001; 0.022.) Patient characteristics did not affect CAD complications in DM patients; a significant difference indicated that poor glycemic control increased the complication of CAD in patients with DM type 2. Glycated albumin examination is recommended for patients with type 2 diabetes with CAD.



Diabetes mellitus, coronary artery disease, HbA1c, glycated albumin

Full Text:



Suyono S. Diabetes melitus di Indonesia. In: Buku ajar ilmu penyakit dalam, 1st Ed., Jakarta, PB PAPDI, 2014; 2315-2318.

International Diabetes Federation. IDF diabetes atlas. 7thEd., Brussels, International Diabetes Federation, 2015; 50-53.

World Health Organization. Use of glycated hemoglobin (HbA1c) in the diagnosis of diabetes mellitus. Diabetes Research and Clinical Practice, 2011; 93(3): 299-309.

Singh A, Donnino R, Weintraub H, and Schwartzbard A. Effect of strict glycemic control in patients with diabetes mellitus on frequency of macrovascular events. The American Journal of Cardiology, 2013; 112(7): 1033-1038.

Majid A. Penyakit jantung koroner: Patofisiologi, pencegahan, dan pengobatan terkini. University Professor. Universitas Sumatera Utara, 2007; 80-94.

PERKI. Pedoman tatalaksana sindrom koroner akut. 4th Ed., Jakarta, Centra Communications, 2015; 3-4.

Kementerian Kesehatan Republik Indonesia. Riset kesehatan dasar. 1st Ed., Jakarta, Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan RI, 2013; 87-94.

Nathan D, Turgeon H and Regan S. Relationship between glycated hemoglobin levels and mean glucose levels over time. Diabetologia, 2007; 50(11): 2239-2244.

Berry C, Noble S, Grégoire J, Ibrahim R, Levesque S, et al. Glycemic status influences the nature and severity of coronary artery disease. Diabetologia, 2010; 53(4): 652-658.

Stratton I. Association of glycemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study. British Medical Journal, 2000; 321(7258): 405-412.

Parrinello C and Selvin E. Beyond HbA1c and glucose: The role of nontraditional glycemic markers in diabetes diagnosis, prognosis, and management. Current Diabetes Reports, 2014; 14(11): 548-557.

Al-Maskari F, El-Sadig M and Norman JN. Original investigation: The prevalence of macrovascular complications among diabetic patients in the United Arab Emirates. Cardiovascular Diabetology 2007; 6: 24. doi:10.1186/1475-2840-6-24.

Fox CS, Coady S, Sorlie PD. Increasing cardiovascular disease burden due to diabetes mellitus the framingham heart study. Circulation. 2007; 115: 1544-1550.

Ma X, Hu X, Zhou J, Hao Y, Luo Y, Lu Z. Glycated albumin is more closely correlated with coronary artery disease than 1,5-anhydroglucitol and glycated hemoglobin A1c. Cardiovascular Diabetology, 2015; 14(1): 16.



  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.