Identification of Risk Factors Characteristics of Transfusion Reaction

Eko Putri Rahajeng, Raehana Samad, Rachmawati Muhiddin


Blood transfusion is an important part of health care. A blood transfusion can be carried out after careful consideration of its risks and benefits. One of the important considerations for blood transfusion is adverse transfusion reaction. Several risk factors for a transfusion reaction are age, gender, repeated transfusion, disease diagnosis, type of blood component, and blood incompatibility. This research is a descriptive study performed at Blood Bank Dr. Wahidin Sudirohusodo Hospital, Makassar, from January to December 2017. The subjects were all patients reported to have an acute transfusion, totaling 104 subjects. The descriptive method was carried out by the calculation of frequency distribution. From January to December 2017, 104 patients with transfusion reactions were obtained, predominantly were male (53.8%), with the lowest age range of ≥ 60 years (27.9%), packed red cell as the most found blood components (82.4%), a history of previous transfusion reactions (72.1%), and a diagnosis of malignancy (53.9%). The history of repeated transfusions is the most common risk factor compared to age, gender, blood component, and patient diagnosis.


Transfusion reaction, risk factors

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Dalimoenthe Najwa Zamalek, et al. Dasar - Dasar Transfusi Darah. Edisi Pertama. Divisi hematologi Klinik Departemen Patologi Klinik, Fakultas Kedokteran Universitas Padjajaran. Bandung. 2011.

Sood AK. Health Benefit of blood donation .2014. Available from : Accesed on Februari 2018

WHO. The clinical use of blood: handbook. Geneva, 2002. Available Accessed 15 Februari 2018.

Kiechl S, Willeit J. Ongoing Controversies Surrounding the Vascular Benefits of Blood Donation. Journal of The American Heart Association. 2001; 104-9.

Chakravarty U, Shewale R, Vartak S, Faizal F, Majethia N. Adverse Reactions of Blood Transfusion: A Study in a Tertiary Care Hospital. International Journal of Scientific Study. 2016. Available from : Accessed 15 Februari 2018.

Peraturan menteri kesahatan republik indonesia no 91 tahun 2015 tentang standar pelayanan transfusi darah. 253-4.

Adewoyin A, Oyewale O, complications of allogeneic blood transfusion: current approach to diagnosis and management. 2015. Available from :

Nix MP, Zundel WB, Harmening. Modern Blood Banking & Transfuion Practices. 5th ed. 2005. Pretransfusion Compatibility Testin. P : 264 – 82

Abbas AK, Lichtman HK, Pillai S. Cellular and Molecular Immunology. 8th ed, Immunologic Tolerance and Autoimmunity. 2015. P : 315 – 38

Mehrdad P, Erfan ZM. Description of Acute Transfusion Reactions in the Teaching Hospitals of Kermanshah University of Medical Sciences, Iran, On International Journal of Hematology – Oncology and Stem Cell Research. 2013. Available from : Accessed 15 Februari 2018.

Lubart E, Segal R,Tryhub N,Sigler E, Leibovitz A. Blood Transfusion Reactions in Elderly Patients Hospitalized in a Multilevel Geriatric Hospital. 2014. Available From : Accessed 15 Februari 2018.

Dasararaju R, Marisa, Marques. Adverse Effects of Transfusion. Available from : Accessed 15 Februari 2018.

Mulyantari NK, Subawa AAN, Yasa Sutirta P. Tranfusion Reactions as an Indicator Service Quality of Blood Transfusion in Sanglah General Hospital Denpasar Bali-Indonesia. Udayana University. Bali .2016. Available from : Accessed 8 April 2018.

Apriastini NKT, Ariawati K. Risk factors of acute blood transfusion reactions in pediatric patients in Sanglah General Hospital. Bali. 2017. Available from Accessed 15 April 2018.

Payung w, Muhiddin R, Arif M. Faktor Reaksi Transfusi Darah Akut. Indonesian Journal Of Clinical Pathology And Medical Laboratory. Vol 2 No 3. 2016. Available

Samsiarah H, Dachlan I. A comparison study on the blood transfusion reaction between the elective and the emergency operation’s patients. 2011. Available from :, Accessed 15 Februari 2018.

Ibrahim UN, Garba N, Tilde ID. Acute Blood Transfusion Reactions in Pregnancy, an Observational Study from North Eastern Nigeria. Journal of Blood Disorders & Tranfusion. 2013. Available from : Https://Www.Omicsonline.Org/Acute-Blood-Transfusion-Reactions-In-Pregnancy-An-Obse

Fatmah. Respons Imunitas Yang Rendah Pada Tubuh Manusia Usia Lanjut. 2006 Available from :

Clevenger B, Kelleher A. Hazards of blood transfusion in adults and children. 2013. Available from : Accessed 15 Maret 2018.

Dubey A. Issues Pertaining To Blood Transfusion In Immunocompromised Patients.2015. Available from.

Squires JE. Risks of Transfusion. 2011.



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