THE DIFFERENCE BETWEEN NEUTROFIL TOTAL, NEUTROPHIL / LYMPHOCYTE AND PLATELETS / LYMPHOCYTE RATIO IN NORMAL PATIENTS, NSTEMI, STEMI

Authors

  • Elisabeth Setianingrum Nusa Cendana University
  • Purwanto A P Department of Clinical Pathology, Faculty of Medicine, Diponegoro University, Semarang

DOI:

https://doi.org/10.24293/ijcpml.v25i3.1445

Keywords:

Neutrofil Absolut, Neutrofil Limfosit Ratio, Platelet Limfosit Ratio, STEMI, NSTEMI

Abstract

 

Acute Coronary Syndrome (ACS) is a Non-ST-Elevation Myocardial Infarct (NSTEMI) and ST-Elevation Myocardial Infarct (STEMI) caused by atherosclerosis vascular, endothelial dysfunction as an acute inflammatory response. Absolute Neutrophils (AN), Neutrophil/Lymphocyte Ratio (NLR), and Platelet/Lymphocyte Ratio (PLR) is a systemic inflammation marker in inflammatory diseases. The research purpose was to compare AN, NLR, and PLR as an inflammatory marker in normal patients and, NSTEMI, STEMI. A cross-sectional observational study of 101 ACS patients at the Dr. Kariadi Hospital, divided into three groups (normal, NSTEMI, and STEMI). Neutrophil and lymphocyte were counted manually. Leukocyte and platelet value were determined by hematology analyzer. Data were analyzed with the Kruskal-Wallis test followed by post hoc Mann-Whitney. There was a difference in AN, NLR value between STEMI and NSTEMI compared to normal patients. There was no significant difference between PLR value.

Downloads

Download data is not yet available.

Author Biography

Elisabeth Setianingrum, Nusa Cendana University

Clinical Pathology

References

Republik Indonesia KK. PROFIL KESEHATAN INDONESIA tahun 2013. 2013. 1-391 p.

Badan Penelitian Dan Pengembangan Kesehatan Kementrian Kesehatan RI. RISET KESEHATAN DASAR. 2013;

Purwanto A. Thrombosis. In: Patofisiologi dan Diagnosis Laboratorium. Semarang: PDS Patologi Klinik Semarang; 2005.

Scharnhorst V, Krasznai K, Veer MV t, Michels R. Rapid detection of myocardial infarction with a sensitive troponin test. Am J Clin Pathol. 2011;135(3):424–8.

Antman E, Bassand JP, Klein W, Ohman M, Lopez Sendon JL, Rydén L, et al. Myocardial infarction redefined - A consensus document of The Joint European Society of Cardiology/American College of Cardiology Committee f or the redefinition of myocardial infarction. J Am Coll Cardiol. 2000;36(3):959–69.

Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, et al. ACC / AHA Practice Guidelines ACC / AHA Guideline Update for the Management of Patients With Unstable Angina and Non – ST-Segment Elevation Myocardial Infarction ” 2002 : Summary Article. Circulation. 2002;6083:1893–901.

Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol [Internet]. 2005;45(10):1638–43. Available from: http://dx.doi.org/10.1016/j.jacc.2005.02.054

Spark JI, Sarveswaran J, Blest N, Charalabidis P, Asthana S. An elevated neutrophil-lymphocyte ratio independently predicts mortality in chronic critical limb ischemia. J Vasc Surg [Internet]. 2010;52(3):632–6. Available from: http://dx.doi.org/10.1016/j.jvs.2010.03.067

Yuksel M, Yildiz A, Oylumlu M, Akyuz A, Aydin M, Kaya H, et al. The association between platelet/lymphocyte ratio and coronary artery disease severity. Anadolu Kardiyol Derg. 2015;15(8):640–7.

Kazi N, Shaikh DINM, Shaikh HZIA, Kazi SA. BACK TO THE BASICS : NEUTROPHIL / LYMPHOCYTE RATIO IN PERIPHERAL BLOOD SMEAR PREDICTS MORBIDITY / MORTALITY IN PATIENTS OF ACUTE M . I . FOLLOWING THE INDEX EVENT. 2013;5(3):189–92.

Oylumlu M, Yildiz A, Oylumlu M, Yuksel M, Polat N, Bilik MZ, et al. Platelet-to-lymphocyte ratio is a predictor of in-hospital mortality patients with acute coronary syndrome. Anatol J Cardiol [Internet]. 2015;15(4):277–83. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=medl&NEWS=N&AN=25413224

Ghaffari S, Nadiri M, Pourafkari L, Sepehrvand N, Movasagpoor A, Rahmatvand N, et al. The predictive Value of Total Neutrophil Count and Neutrophil/Lymphocyte Ratio in Predicting In-hospital Mortality and Complications after STEMI. J Cardiovasc Thorac Res [Internet]. 2014;6(1):35–41. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3992730&tool=pmcentrez&rendertype=abstract

Demirağ MK, Bedir A. Evaluation of preoperative neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in patients undergoing major vascular surgery. Türk Göğüs Kalp Damar Cerrahisi Derg. 2013;21(4):930–5.

Zazula AD, Précoma-Neto D, Gomes AM, Kruklis H, Barbieri GF, Forte RY, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome. Arq Bras Cardiol. 2011;96(1):31–6.

Bekler A, Gazi E, Yılmaz M, Temiz A, Altun B, Barutçu A, et al. Could elevated platelet-lymphocyte ratio predict left ventricular systolic dysfunction in patients with non-ST elevated acute coronary syndrome? Anadolu Kardiyol Derg. 2015;15(5):385–90.

Temiz A, Gazi E, Gungor O, Barutcu A, Bekler A, Binntoglu E, et al. Platelet/lymphocyte ratio and risk of in-hospital mortality in patients with ST-elevated myocardial infarction. Med Sci Monit [Internet]. 2014;20:660–5. Available from: http://www.medscimonit.com/abstract/index/idArt/890152

Downloads

Submitted

2019-01-25

Accepted

2019-01-26

Published

2019-04-13

How to Cite

[1]
Setianingrum, E. and P, P.A. 2019. THE DIFFERENCE BETWEEN NEUTROFIL TOTAL, NEUTROPHIL / LYMPHOCYTE AND PLATELETS / LYMPHOCYTE RATIO IN NORMAL PATIENTS, NSTEMI, STEMI. INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY. 25, 3 (Apr. 2019), 268–273. DOI:https://doi.org/10.24293/ijcpml.v25i3.1445.

Issue

Section

Articles