COMPARISON OF HEPCIDIN LEVELS IN CHILDREN WITH AND WITHOUT SOIL-TRANSMITTED HELMINTHS INFECTION

Dewi Saputri, Dewi Saputri, Yunilda -, Yunilda Yunilda, Almaycano Ginting

Abstract


Helminths infection  is one of diseases that still occurs in society. The helminth infection caused by Soil-Transmitted Helminths (STH) group, which is Ascaris lumbricoides, Trichuris trichiura, and hookworm in human can cause chronic bleeding which results in decreased iron storage of the body and ultimately causes iron deficiency anemia. Hepcidin is a liver hormone which regulate iron metabolism and can function as marker of inflammation and iron deficiency. A cross-sectional study was conducted in Mei-Oktober 2018 on 28 STH infection and 140 non-infection subjects. The collected stool samples were analyzed using the Kato-Katz method  to determine the presence of STH infection and  the degree of infection. Urine samples were processed and their hepidin levels were measured by the sandwich-ELISA method. Measurements are made using the Spectrophotometer. Difference of  numeric variables was analyzed using wilcoxon Test. The prevalence of STH infection was 16.67%. The infection prevalence of each STH species is as follows;Trichuris trichiura 10.7%, Ascaris lumbricoides 4.8% and hookworm 3%. Based on the amount of  STH species that infect, single infection incidence 14.9% and mixed infection 1.8%. Of  28 positive stool samples containing STH eggs, 92.8% s samples were found with the mild degree of infection, 3.6%  with moderate degree of infection and also 3.6% with severe degree of infection. Median hepcidin levels in the infected and uninfected group did not differ significantly (p> 0.05). There were no significant differences in hepsidin levels in children with and without Soil-Transmitted Helminths infection.


Keywords


Hepcidin, Soil-Transmitted Helminths, Anemia, Iron Deficiency

References


Sudomo, M. Penyakit Parasitik yang Kurang Diperhatikan di Indonesia, Orasi Pengukuhan Profesor Riset Bidang Entomologi dan Moluska, Jakarta.2008

WHO. Reaching the People Left Behind : a Neglected Success, 2007[access Nopember 10, 2017]. Available in https://www.who.int/dg/speeches/detail/reaching-the-people-left-behind-a-neglected-success.

Manalu, S.M., Biran, S.I. Infeksi Cacing Tambang, Cermin Dunia Kedokteran Vol. 19 No.4, Oktober- Desember.2006.

Ginting A. Faktor yang berhubungan dengan kejadian kecacingan pada anak sekolah dasar di desa tertinggal kecamatan pangururan kabupaten samosir tahun 2008 [Skripsi]. Medan : Fakultas Kedokteran Universitas Sumatra Utara. 2009. Available in http://repository.usu.ac.id.

Larocque R, Casapia M, Gotuzzo E, and Gyorkos T.W. Relationship Between Intensity of Soil-Transmitted Helminth Infections and Anemia During Pregnancy. Am. J. Trop. Med. Hyg., 2005;73(4):783-9.

Nurdiati, D.S., Sumarni, S., Suyoko, hakimi, M. and Winkvist, A. Impact of Intestinal Helminth Infection On Anemia And Iron Status During Pregnancy : A Community Based Study In Indonesia. Southeast Asian J Trop Med Public Health.2001;32(1):14-22

Siagian UL, Husaini, Mahdin A, et al. Anemia gizi: Suatu studi kompilasi informasi dalam menunjang kebijakan nasional dan pengembangan program. Kerjasama Direktorat bina gizi masyarakat dengan Puslitbang gizi, Bogor. 1989.

Siregar CD. Pengaruh infeksi cacing usus yang ditularkan melalui tanah padapertumbuhan fisik anak usia sekolah dasar. Sari Pediatri. 2006;8(2):112-117.

Tessitore, N., Solero, G.P., Lippi, G, et al, The role of iron status markers in predicting response to intravenous iron in haemodialysis patients on maintenance erytropoetin. Nephrol Dial Transplant, 2001;16:1416-1423.

Macdougall IC, Malyszko J, Hider RC, Bansal SS. Current status of Measurement of Blood Hepcidin Levels in Chronic Kidney Disease. Clin J Am Soc Nephrol 5. 2010;1681–1689.

Ginting A. Korelasi kadar hepsidin dan reticulocyte hemoglobin pada penderita gagal ginjal terminal dengan hemodialisis reguler. Majalah Kedokteran Nusantara The Journal of Medical School. 2016;51(3):138-141.

Pigeon C, Ilyin G, Courseloud B. et.al, A new mouse liver-spesipic gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J BiolChem, 2001;276:7811-7819.

Zaritsky J, Young B, Gales B, et al. Reduction of Serum Hepcidin by Hemodiatysis in Pediatric and Adult Patients. Clin J Am Soc Nephrol 5.2010;1010-1014.

Cherian,S., Forbes, D.A., Cook, A.G., Sanfilippo,F.M., Kemma,E.H., Swinkels,D.W., et al. An Insight Into the Relationships between Hepcidin, Anemia, Infections and Inflammatory Cytokines in Pediatric Refugee: A Cross-Sectional Study. Plos ONE .2008;3(12) : e4030

Ayoya MA, Spiekermann-Brouwer, GM, Stoltzfus RJ, Nemeth E, Habicht J, et.al. α1-Acid glycoprotein, hepcidin, c-reactive protein, and serum ferritin are correlated in anemic schoolchildren with Schistosomahaematobium. Am J Clin Nutr. 2010;91:1784-90.

Elmi, Sembiring T, Dewiyanti BS, Hamid ED, Pasaribu S, Lubis CP. Status Gizi dan infestasi cacaing usus pada anak sekolah dasar. E-USU repository. Universitas Sumatera Utara, Indonesia. 2004.

Kuong K, Fiorentino M, Perignon M, Chamnan C, Berger J,Sinuon M. Cognitive performance and iron status are negatively associated with hookworm infection in Cambodian Schoolchildren. Am. J. Trop.Med.Hyg.2016; 95(4):856-863

Fauzi RRT, Permana O, Fetritura Y. Hubungan kecacingan dengan status gizi siswa sekolah dasar di Kecamatan Pelayangan jambi. 2013.

Cruz AA, Copper PJ, Figueiredo CA. Global issues in allergy and immunology: Parasiticinfections and allergy. J Allergy Clin Immunol. 2017;140(5):1217-1228.




DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1471

Refbacks

  • There are currently no refbacks.