Comparison of Hepcidin Levels in Children with and without Soil-Transmitted Helminths Infection

Dewi Saputri, Yunilda Andriyani, Almaycano Ginting

Abstract


Helminths infection is one of the diseases that still occur insociety. The helminth infection caused by the
Soil-Transmitted Helminths (STHs) group, which is Ascaris lumbricoides, Trichuris trichiura, and hookworm in human can
cause chronic bleeding resulting in decreasir on storage in the body and increased level of hepcidin. Hepcidin is a liver
hormone which regulates iron metabolism and can function as marker of inflammation and iron deficiency. This study aimed
to compare the hepcidin levels in STH-infected and non-infected children. A cross-sectional study was conducted between
May and October 2018 on 28 STH infected and 140 non-infected subjects. The collected stool samples were analyzed using
the Kato-Katz method to determine the presence of STH infection and the degree of infection. Urine samples were
processed, and their hepcidin levels were measured using a Sandwich-ELISA method. Measurement was made using a
Spectrophotometer. The difference of numeric variables was analyzed using Wilcoxon test. The prevalence of STH infection
was 16.66%. The prevalence of Trichuris trichiura 10.71%, Ascaris lumbricoides 4.76% and hookworm 2.97%. The prevalence
of a single infection was 14.88% and mixed infection 1.78%. Based on the intensity of infection, 15.48% of subjects were mild
infection, 0.59% moderate infection, and 0.59% severe infection. Hepcidin levels in the infected and uninfected group did
not differ significantly (p=0.978). There were no different hepcidin levels in children with and without soil-transmitted
helminths infection.


Keywords


Hepcidin, soil-transmitted helminths, infection, inflammation

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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1471

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