ANALYSIS OF RED BLOOD CELL DISTRIBUTION WIDTH COEFFICIENT OF VARIATION ON STROKE PATIENT
DOI:
https://doi.org/10.24293/ijcpml.v25i1.1482Keywords:
Stroke, ischemic stroke, hemorrhagic stroke, RDW, RDW-CVAbstract
Stroke is a functional disorder attributed to acute focal or global brain injury by vascular cause and persists more than 24 hours. Stroke is divided into ischemic and hemorrhagic strokes. Red Blood Cell Distribution Width (RDW) is a measurement of erythrocyte volume variation in blood circulation. Increased RDW reflects the inflammation that plays a role in the development of atherosclerosis in stroke. This study aims to analyze differences in RDW-CV values in patients with stroke. The design was cross-sectional with a retrospective approach, secondary data from medical records of inpatients with stroke from January to December 2016 at the Dr. Wahidin Sudirohusodo Hospital. The study population consisted of 490 patients aged ≥ 18 years old. The Kruskal-Wallis, Mann-Whitney, and Anova one way tests were used to analyze differences in RDW-CV values in patients with ischemic and hemorrhagic stroke. Mann-Whitney test results showed no significant difference in RDW-CV values between groups of ischemic and hemorrhagic stroke (p 0.96). Kruskal-Wallis and Anova one way tests showed no significant difference in RDW-CV values between four groups of patient outcomes in ischemic and hemorrhagic stroke (p 0.13 and p 0.35 consecutively). There were no significant RDW-CV values between ischemic and hemorrhagic stroke. There was no significant difference between RDW-CV values of four groups of patient outcomes in ischemic and hemorrhagic stroke. RDW-CV values cannot be used to distinguish both ischemic and hemorrhagic stroke, including the prediction of stroke mortalityDownloads
References
WHO. Multinational monitoring of trends and determinants in cardiovascular disease (MONICA Project) Manual. WHO. 1988; 105-14.
Setyopranoto I. Stroke: Gejala dan penatalaksanaan. Cermin Dunia Kedokteran. 2011; 38(4): 247-50.
Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008; 371: 1612-23
Ghani L, Mihardja LK, Delima. Faktor risiko dominan penderita stroke di Indonesia. Buletin Penelitian Kesehatan. 2016; 44(1): 49-58.
Isik T, Ayhan E, Kurt M, Tanboga IH, Kaya A, Aksakal E. Is red cell distribution width a marker for the presence and poor prognosis of cardiovascular disease?. The Eurasian Journal of Medicine. 2012; 44: 169-71
Curry CV, Staros EB. Red Cell Distribution Width (RDW) [download date 04 June 2017]. Available from http://emedicine.medscape.com/article/2098635-overview.
Bain BJ, Lewis SM. Basic hematological techniques. In: Dacie and Lewis practical hematology. 11th Ed., London, Churchill Livingstone/Elsevier, 2012; 41-2.
Vajpayee N, Graham SS, Bem S. Basic examination of blood and bone marrow. In: Henry's clinical diagnosis and management by laboratory methods. 22nd., Philadelphia, Elsevier/Saunders, 2011; 510-526.
Soebrata RG. Penuntun laboratorium klinik. Jakarta, Dian Rakyat, 2002; 39-42.
Ani C, Ovbiagele B. Elevated red blood cell distribution width predicts mortality in persons with known stroke. Journal of the Neurological Sciences, 2009; 277: 103-08.
Kara H, Degirmenci S, Bayir A, Ak A, Akinci A, Dogru A, Akyurek F, Kayis SA. Red cell distribution width and neurological scoring systems in acute stroke patients. Neuropsychiatric Disease and Treatment, 2015; 11: 733-39.
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Critical Reviews in Clinical Laboratory Science Early Online, 2014; 1-20.
Jia H, Li H, Zhang Y, Li C, Hu Y, Xia C. Association between Red Blood Cell Distribution Width (RDW) and Carotid Artery Atherosclerosis (CAS) in patients with primary ischemic stroke. Archives of Gerontology and Geriatrics, 2015; 61: 72-5.
O'Donnell MJ, Xavier D, Liu L, Zhang H, Chin SL, Rao-Melacini P, Rangarajan S, et al. Risk factor for ischemic and intracerebral hemorrhagic stroke in 22 countries (the interstroke study): A case-control study. Lancet. 2010; 376: 112-23.
Setyopranoto I. Stroke: Gejala dan penatalaksanaan. Cermin Dunia Kedokteran, 2011; 185: 247-50.
Vijayashree R, Abirami VR, Govindaraju S, Ramesh Rao K. Relevance of Red Cell Distribution Width (RDW) determination in stroke: A case-control study. International Journal of Scientific and Research Publications, 2014; 4(11): 1-5.
Abdinur MA, Yong X. Progress in red blood cell distribution width and cardiovascular disease. IOSR Journal of Dental and Medical Sciences, 2016; 15(9): 128-31.
Lippi G, Filippozzi L, Montagnana M, Salvagno GL, Franchini M, et al. Clinical usefulness of measuring red blood cell distribution width on admission in patients with acute coronary syndromes. Clinical Chemical Laboratory Medicine, 2009; 47: 353-57.
Cetin M, Kocaman S, Bostan M. Red blood cell distribution width and its association with coronary atherosclerotic burden in patients with stable angina pectoris. Europe Journal General Medicine, 2012; 9(1): 7-13.
Bujak K, Wasilewski J, Osadnik T, Jonczyk S, Kolodziejska A, Gierlotka M, Gasior M. The prognostic role of red blood cell distribution width in coronary artery disease: A review of the pathophysiology. Hindawi Publishing Corporation Disease Marker, 2015; 1-12.
