Rini Rahmayani, Adi Koesoema Aman, Santi Safril


The cause of metabolic syndrome is still not known for sure, but it is suspected that the pathophysiology of metabolic syndrome is associated with insulin resistance and central obesity. Researchers have attempted to evaluate insulin resistance using various serum lipid concentration ratio. This study was to observe the association between insulin resistance and lipid profile ratio using HOMA-IR in metabolic syndrome patients. This study was a cross-sectional that was conducted in Inpatient and Outpatient Adam Malik Hospital during March 2016 - April 2016. Subjects were patients with metabolic syndrome criteria according to the International Diabetic Federation 2005. All samples were examined for their waist circumference, weight, height, blood pressure, insulin, serum glucose, total cholesterol, HDL cholesterol, LDL cholesterol, Triglycerides. Among sixty-six patients in the study 40 (60.6%) were male and 26 (39.4%) female. In this study, there was a significant correlation between HOMA-IR with CT/HDL ratio (r: 0.244 p <0.05); and there was no correlated HOMA-IR, and TG/HDL ratio (r: 0.086 p > 0.05) and there was no correlation between HOMA-IR and LDL/HDL (r: 0.336 p > 0.05). There was a significant relationship between insulin resistance and ratio CT/HDL


HOMA-IR, lipid profile ratio, metabolic syndrome

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Mukherjee B, Hossain CM, Mondal L, Paul P, Ghost MK, et al. Obesity and insulin resistance: An abridged molecular correlation. Lipid Insights. 2013; 6: 1–11.

Byrne CD. The global burden of the metabolic syndrome and its consequences for diabetes and cardiovascular. Dalam: Metabolic syndrome. England, John Wiley & Sons Ltd. 2005; 1.

Anwar TB. Dislipidemia sebagai faktor resiko penyakit jantung koroner. Fakultas Kedokteran. e-Universitas Sumatera Utara. 2004; 2.

Mittal S. The metabolic syndrome in clinical practice. London, Springer –Verlag, 2008; 40.

Merentek E. Resistensi insulin pada diabetes melitus tipe 2. Cermin

dunia kedokteran. Poliklinik Endrokrin Metabolik

Bagian Penyakit Dalam Rumah Sakit Umum Gowa, Makasar. 2006; 150: 39-41.

Chaudari SP, Usmani MH. Baghel PK. Clinical profile of metabolic syndrome its reference to insulin resistance (HOMA-IR). Journal Indian Academy of Clinical Medicine, 2012; 13(4): 286 -190.

Chaves AG, Mendia LES, Argueta SE. Elevated triglycerides/HDL cholesterol associated with insulin resistance. Cirugia y Cirujanos, 2011; 79(2): 115 – 9.

Byun RA, Lee SW, Lee HS, Shim KW. What is the most appropriate lipid profile ratio predictor for insulin resistance in each sex? A cross–sectional study in Korean population (The Fifth Korea National Health and Nutrition Examination Survey). Diabetology and Metabolic Syndrome, 2015; 7: 59.

Mostafa SA. The association of the triglyceride-to-HDL cholesterol

ratio with insulin resistance in White European and South Asian men and women. Plos One, 2012; 7(12): 1-7.

Soegondo S. Atherogenic dyslipidemia and the metabolic syndrome clinical practice. Acta Medical Indonesia, 2001; 37: 177 – 83.

Vigil L and Goday A. Metabolic syndrome and insulin resistance are associated with chronic kidney disease in nondiabetic with abdominal obesity. International journal of clinical medicine, 2011; 367 – 77.

Marjani A. Waist circumference, body mass index, hip circumference and waist-to-hip ratio in type 2 diabetes patients in Gorgan, Iran. Journal of Clinical and Diagnostic Research, 2011; 5(2): 201-5.

Sudoyo AW. Buku ajar ilmu penyakit dalam. Jilid II, Ed V., Jakarta, Interna Publishing, 2009; 2550-2552.

Olivia, A. Examining the association between body mass index and weight-related quality of life in black and white women. Quality of Life Journal, 2011; 7(3): 309 – 22.

Sumner AE. Fasting triglyceride and the triglyceride-HDL

cholesterol ratio are not markers of insulin resistance in African

Americans. Archives of Internal Medicine, 2005; 165(12):


Huguette YM. Prevalence of insulin resistance in obese Cameroonian women. Journal of Diabetes and Endocrinology, 2010; 1:19–6.

He J. The TG/HDL-C ratio might be a surrogate for insulin resistance Chinese non-obese Women. International Journal of Endocrinology, 2014; 1-7.

McLaughlin T. Use of metabolic markers to identify overweight individuals who are insulin resistant. Annals of Internal Medicine, 2003; 139(10): 802–9.

Umboh A. Hubungan antara resistensi insulin dan tekanan darah pada anak obese. Sari Pediatri, 2007; 8(4): 289 – 93.

Shinsha S and Akhter QS. Correlation study of insulin resistance and essential hypertension among Bangladeshi male volunteers. Journal of Young Pharmacists, 2015; 7(3): 201-5.

Vangaripu J. Association between liver insulin resistance and

cardiovascular risk factors. Journal of Internal Medicine, 2012; 272: 402–408.

Ku BJ. Serum ferritin is inversely correlated with

serum adiponectin level: Population-based cross-sectional study. Disease Markers, 2009; 27: 303–310.

Chu MA. HOMA-IR and its association with metabolic risk factors among Korean adolescent. Korean J Gastroenterolog Nutric, 2011; 14(4): 376 -384.

Shentil N. Association between liver insulin resistance and cardiovascular risk factors. Journal of Internal Medicine, 2012; 272: 402–8.

Wilcox G. Insulin and insulin resistance. Clinical Biochemistry Review, 2005; 26(2): 19 – 39.

Ray S, Talukdar A, Sonthalia N, Saha M, Kundu S, et al. Serum lipoprotein ratio as marker of insulin resistance: A study among non-diabetic acute coronary syndrome patient with impaired fasting glucose. Indian Journal Medical Research, 2015; 141: 62-7.

Jung CH. The relationship of adiponectin/leptin ratio with

homeostasis model assessment insulin resistance index and metabolic syndrome in apparently healthy Korean male adults. Korean Diabetes J, 2010; 34: 237-43.

Hassan EN, El-Masry SA. Obesity degree and cardiometabolic risk among school students. Life Science Journal, 2012; 9(3): 293 – 01.

Hancox RJ. Correlation between measure of insulin resistance in fasting and non-fasting blood. Diabetology and Metabolic Syndrome, 2011; 3: 45-7.

Madsen CR. Tissue-specific insulin signaling. Metabolic syndrome and cardiovascular disease. Arterioscler. Thromb Vasc Biol, 2012; 32(9): 2052 – 9.

Leslie B. Metabolic syndrome. Historical perspective. The American Journal of Medical Science, 2005; 330(6): 264 – 8.

Lee UP. Insulin, lipid profiles and measures of fatness in

Taiwanese women in relation to duration of residence in

Australia. 2007; Asia Pac J Clin Nutr, 2007; 6 (2): 254-261.

Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, et al. Relation between lipid profile and metabolic syndrome, insulin resistance and serum high molecular adiponectin in Japanese community-dwelling adults. Lipid in Health and Disease, 2011; 10: 79.

Mohiuddin SM. The association between serum lipid ratio and insulin resistance among subject with impaired glucose tolerance in Pakistan. University of Oslo Institute of Health and Society. Department of Community Medicine, Pakistan. Thesis. 2013; 43.



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