INFECTION OF CYTOMEGALOVIRUS (CMV) IN CHOLESTASIS INFANT WITH BILIARY ATRESIA

Lasmauli Situmorang, Bagus Setyoboedi, Sjamsul Arief, Gondo Mastutik

Abstract


Biliary atresia (BA) is extrahepatic cholestasis that result death within the first 2 years if the diagnosis and intervention are delayed. Etiology and pathogenesis of  BA is still uncertain. Viral infections are thought to be one of the causes, including Cytomegalovirus (CMV). Cytomegalovirus infection is more common in intrahepatic cholestasis than extrahepatal such as BA. The data for Cytomegalovirus infection in cholestatic infants with BA is still lacking. This study compared the incidence of CMV infection in cholestatic infants with biliary atresia and non-biliary atresia. A cross-sectional study in December 2017 - August 2018 in cholestatic infants aged 1-6 months. Liver biopsy and histopathological examination were performed on cholestatic infants followed by PCR CMV examination, result of PCR examination were compared between BA and non-BA infant. Statistical analysis of chi-square was used with p<0.05 were significance. Thirty-seven children were obtained during the study period. Sixteen children showed BA and twenty-one children were non-BA. Girls were found more in BA than boys, but there were no differences between the groups (p= 0.163). There were differences in body weight (p= 0.002) age (p= 0.009), birth weight (p= 0.02) and gestational age (p= 0.03) between children with BA and non-BA. There was no significant difference in the incidence of CMV infection in cholestatic infants with BA and non-BA (p = 0.338). Cytomegalovirus infection in cholestatic infants with BA is less than cholestatic infants who are non-BA.

Keywords


Biliary atresia, Cholestasis, Cytomegalovirus, Polymerase chain reaction

References


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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1496

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