CORRELATION OF PROCALSITONIN LEVEL WITH SEPSIS DEGREES BASED ON SOFA SCORE

Citra Novita, Soeprapto Maat, Betty Agustina Tambunan

Abstract


Background. Sepsis is defined as a life-threatening organ dysfunction condition caused by dysregulation of host response towards infection. Sepsis is one of the leading causes of death in medical emergency. A recent study revealed 18 millions of sepsis occur annually with a mortality rate of 30%, so early diagnosis in assessing sepsis severity is necessary as a guide for early and specific therapy. Organ dysfunction in sepsis patients is associated with high mortality, assessed by Sequential Organ Failure Assessment (SOFA) criteria. Procalcitonin is widely used for diagnosing, monitoring, and prognosis sepsis.

Aim This study aimed to analyze the correlation of procalcitonin level with sepsis severity based on SOFA score.  Method. This was an observational cross-sectional study. Samples were collected from December 2017-February 2018 of 72 patients. Each patient was calculated by SOFA score and underwent procalcitonin examination using an immunochromatography method by RAMP. Results. Samples from 72 patients who met the criteria, were analyzed consisting of 37 mailes(51.4%) and 35 females(48.6%), aged 23-77 years, with mean±SD 47.4±14.02 years. The range of SOFA score was 0-16 with mean±SD 6.47±3.61, while procalcitonin levels 0.20-200 ng/mL mean±SD 21.03±14.63 ng/mL. There was a significant correlation between procalcitonin level and SOFA score (r=0.752;p<0.0001).Discussion. This suggests that procalcitonin may illustrate the severity of sepsis patients. The higher the procalcitonin, the more severe the sepsis.Conclusions and recommendations. SOFA score and procalcitonin examinations should be performed routinely in patients with sepsis to assess prognosis (severity) for earlier pretreatment so that the mortality rate can be lowered.

Keywords


Procalcitonin level, sepsis severity, SOFA score

References


Azevedo J, Torres O, Beraldi R, Ribas C, Malafaia O. Prognostic evaluation of severe sepsis and septic shock: Procalcitonin clearance vs δ Sequential Organ Failure Assessment. J Crit Care. 2015;30(1):219.e9-219.e12. Available from:

http://dx.doi.org/10.1016/j.jcrc.2014.08.018 [Accessed 12 Mei 2018]

Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (sepsis-3). JAMA. 2016;315(8):801–10.

Marik PE, Taeb AM. SIRS, qSOFA and new sepsis definition. J Thorac Dis. 2017;9(4):943–5.

Annam V, Maleedhu P, Bhaskar MV, Venugopal L. Evaluation of Serum Procalcitonin Levels and Sequential Organ Failure Assessment Score in Assessing the Severity and Outcome of Sepsis. Int J Sci Study. 2016;3(10):48–51.

RSUD Dr. Soetomo. Data Kejadian Sepsis 2014. Surabaya; 2015.

Joen JS, Ji SM. Diagnostic value of procalcitonin and CRP in critically ill patients admitted with suspected sepsis. J Dent Anesth Pain Med. 2015;15(3):135-140. Available from:

https://synapse.koreamed.org/DOIx.php?id=10.17245/jdapm.2015.15.3.135 [Accessed 20 Mei 2018]

RAMP. Peran Procalcitonin dalam penanganan sepsis. Setia Medika. 2017;4–8.

Sakr Y, Elia C, Mascia L, et al. The influence of gender on the epidemiology of and outcome from severe sepsis. Critical Care 2013; Volume 17, p.R50.

Pietropaoli, A., Glance, L., Oakes, D., Fisher S. Gender differences in mortality inpatient with severe sepsis and sepsis shock. Gend Med. 2010;5(7):422–37.

Iskander KN, Osuchowski MF, Stearns-Kurosawa DJ, Kurosawa S, Stepien D, et al. Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding. Physiol Rev. 2013; 93(3):1247-1288.

Artero A, Zaragoza R, Nogueira JM. Epidemiology of Severe Sepsis and Septic Shock. Sev Sepsis Septic Shock. Underst a Serious Kill. 2012;3-25. Available from: http://www.intechopen.com/books/severe-sepsis-and-septic-shock-understanding-a-serious-killer/epidemiology-of-severe-sepsis-and-septic-shock [Accessed 2 Juni 2018]

Kurosawa S, Osuchowski MF, Valentine C, Remick DG. The pathogenesis of sepsis. Annu Rev Pathol. 2011;6:19–48.

Sudhir U, Venkatachalaiah RK, Kumar TA, Rao MY, Kempegowda P. Significance of serum procalcitonin in sepsis. Indian J Crit Care Med. 2011;1(11):1–5.




DOI: http://dx.doi.org/10.24293/ijcpml.v25i3.1497

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