Hypotestosterone in Male with Obesity

Liong Boy Kurniawan

Abstract


Obesity can be defined as the excess of body fat. The prevalence of obesity worldwide increases in the last decades and
causes a higher risk of cardiovascular diseases. Male subjects tend to develop visceral (abdominal) obesity, which produces
pro-inflammatory adipokines. Obesity in males is associated with low testosterone levels. Several mechanisms have been
proposed to explain the link between male obesity and hypotestosterone, including increased aromatization of
testosterone to form estradiol, suppressing the Hypothalamus-Pituitary (HPT) axis due to pro-inflammatory adipokines, and
decrease of Sex Hormone Binding Globulin (SHBG) production. Because hypotestosterone in males with obesity is a
functional but reversible condition, it is essential to screen testosterone levels in obese males for early intervention and
treatment.


Keywords


Male, obesity, visceral, testosterone, hypotestosterone

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References


Wilborn, C, Beckham J, Campbell B, Harvey T,

Galbreath M, Bounty PL, et al. Obesity: Prevalence,

theories, medical consequences, management, and

research directions. Journal of the International

Society of Sport Nutrition, 2005; 2(2): 4-31.

Rachmi CN, Li M, Baur LA. Overweight and obesity in

Indonesia: Prevalence and risk factors- a literature

review. Public Health, 2017; 147: 20-29.

Fui MNT, Dupuis P, Grossmann M. Lowered

testosterone in male obesity: Mechanisms, morbidity,

and management. Asian Journal of Andrology, 2014;

: 223-231.

Guyton AC, Hall JE. Metabolism and temperature

regulation. In textbook of medical physiology.

Philadelphia, Saunders Elsevier, 2011; 843-857.

WHO. Obesity and overweight [Online]. 2017

Available: http://www.who.int/mediacentre/

factsheets/fs311/en/ (accessed 1 May, 2018).

Despres JP. Abdominal obesity: The most prevalent

cause of the metabolic syndrome and related

cardiometabolic risk. European Heart Journal

Supplements, 2006; 8(supplement B): B4-B12.

Hohl A. Testosterone from basic to clinical aspects.

Springer, Switzerland, 2017; 149-159.

MayoClinic. Testosterone, total, bioavailable, and free,

serum [Online]. 2018. Available:https://www.

mayomedicallaboratories.com/test-catalog/

Clinical+and+Interpretive/83686 (accessed 15 May,

.

Guyton AC, Hall JE. Reproductive and hormonal

functions of the male. In textbook of medical

th physiology. 12 Ed., Philadelphia, Saunders Elsevier,

; 973-986.

Durdiakova J, Ostatnikova D, Celec P. Testosterone

and its metabolites-modulators of brain functions.

Acta Neurobiol Exp, 2011; 71: 434-454.

Kelsey, TW, Li LQ, Mitchell RT, Whelan A, Anderson RA,

Wallace WHB. A validated age-related normative

model for male total testosterone shows increasing

variance but no decline after age 40 years. PLoS One,

; 9(10): e109346.

Gronowski A M. Reproductive Disorders. In: Burtis CA,

Ashwood ER, Bruns DE. (eds.) Tietz textbook of clinical

th chemistry and molecular diagnostics. 6 Ed., St. Louis,

Saunders Elsevier, 2008; 780-801.

Cooper LA, Page ST, Amory JK, Anawalt BD,

Matsumoto AM. The association of obesity with sex

hormone-binding globulin is stronger than the

association with aging – implications for the

interpretation of total testosterone measurements.

Clin Endocrinol (Oxf), 2015; 83: 828-833.

Melmed S, Polonsky KS, Larsen P, Kronenberg H.

Williams textbook of endocrinology. Philadelphia,

Elsevier, 2016; p645-698.

Krakowsky Y, Conners W, Morgentaler A. Serum

concentrations of sex hormone-binding globulin vary

widely in younger and older men: Clinical data from a men's health practice. Eur Urol Focus, 2017; 1-7.

Stanczyk FZ, Bretsky P. Biosynthesis, transport, and

metabolism of steroid hormones. In: Henderson BE,

Ponder B, Ross RK. (eds.) Hormones, genes, and

cancer. New York, Oxford University Press, 2003;

-37.

Hammond GL. Sex hormone-binding globulin and the

metabolic syndrome. In: Winters SJ, Huhtaniemi IT.

nd (eds.). Male hypogonadism. 2 Ed., New York,

Humana Press, 2017; 305-324.

Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H,

Eriksson KL, et al. Relationship between testosterone

levels, insulin sensitivity, and mitochondrial function

in men. Diabetes Care, 2005; 28: 1636-1642.

Bhasin S. Effect of testosterone administration on fat

distribution, insulin sensitivity, and atherosclerosis

progression. Clinical Infectious Disease, 2003; 37(2):

S142-149.

Bianchi VE. Metabolic syndrome, obesity paradox, and

testosterone level. Endocrinol Metab Synd, 2015; 4(2):

-16.

Pasquali R, Vicennati V, Gambineri A, Pagotto U.

Sex-dependent role of glucocorticoids and

androgens in the pathophysiology of human obesity.

International Journal of Obesity, 2008; 32: 1764-1779.

Mogri M, Dhindsa S, Quattrin T, Ghanim H, Dandona P.

Testosterone concentration in young pubertal and

post-pubertal obese males. Clin Endocrinol (Oxf),

; 78(4): 593-599.

Wang C, Jackson G, Jones TH, Matsumoto AM, Nehra

A, Perelman MA, et al. Low testosterone associated

with obesity and the metabolic syndrome contributes

to sexual dysfunction and cardiovascular disease risk

in men with type 2 diabetes. Diabetes Care, 2011; 34:

-1673.

Tremellen K, Pearce K. Nutrition, fertility, and human

reproductive function. Florida, CRC Press, 2015;

-261.




DOI: http://dx.doi.org/10.24293/ijcpml.v27i2.1525

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