ANALYSIS OF D-DIMER LEVELS IN DEEP VEIN THROMBOSIS PATIENTS

Anton Triyadi

Abstract


ABSTRACT

 

Background: The incidence of DVT reported 84 cases per 100,000 each year,  30-50% of untreated DVT are at risk for developing pulmonary embolism, which cause the increasing of mortality rate about 12%. The accuracy and rapidity of establishing a diagnosis of DVT is needed to minimize the risk of complications and prevent unnecessary anticoagulant therapy without waiting for the results of a diagnostic examination using ultrasound. This study was conducted to determine the diagnostic value of plasma D-dimer levels against Doppler ultrasound in diagnosing DVT so that it can help clinicians in the removal of rapid and accurate diagnostic tools in diagnosis of DVT.

Methods: This is a retrospective study using data from medical records, conducted at the Medical Record Installation of RSUP Dr. Wahidin Sudirohusodo, Makassar by taking data on patients with DVT accompanied by the results of D-dimer and Doppler ultrasound examinations within periode from January 2018-December 2018. D-dimer tests were examined using an immunoturbidimetry method with a reference value <0.5 μg / mL.

Results: A total of 33 samples were obtained with average of D-dimer value was higher in positive Doppler (5.29) compared to negative (2.31), although not statistically significant (p> 0.05), mean of Wells score was more higher in positive Doppler height (4.74) compared to negative (4.17), although not statistically significant (p> 0.05). The diagnostic test value of D-dimer was 92.6% of Sensitivity, 33.3% of Specificity, 86.2% of Positive Prediction Value, 50.0% of Negative Prediction Value and 81.8% of Accuracy.

 

Conclusion: D-dimer test can be used both for screening and diagnostic test with cut-off value ≥ 2 μg / mL


Keywords


Deep Vein Thrombosis, D-dimer, Doppler ultrasound

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DOI: http://dx.doi.org/10.24293/ijcpml.v26i2.1531

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